该工作以“DNA computing with error correction function in cells for cancer diagnosis and targeted therapy”发表于国际期刊Sensors and Actuators: B. Chemical上,该文章第一作者为天津科技大学博士研究生吴浩天,指导教师为天津科技大学/天津市特聘...
DNA 在细胞中发生的变化是一项关键步骤,包括单核苷酸变异和复制错误。这些变化可能导致基因功能的改变、细...
that we realized that we could harness its function as a genetic engineering technology 我们意识到可以驾驭它的功能,把它当做一种基因工程技术 a way for scientists to delete or insert specific bits of DNA into cells with incredible precision 一种可以让科学家用难以置信的精准度来消除或插入特定DNA片段...
67. Parsons, R., et al., Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell, 1993. 75(6): p. 1227-36.
This chapter discusses the structure and function of DNA. DNA occupies a critical role in cells, because it is the source of all intrinsic genetic information. Chemically, DNA is a very stable molecule, a characteristic important for a macromolecule that may have to persist in an intact form ...
NAD+ contributes to our cells’ ability to transform the food we eat into cellular energy powering the healthy functions of our cells. These functions include boosting energy metabolism, repairing DNA, protecting cells from damage, promoting healthy brain and cardiovascular function, and reducing inflam...
involve interactions with other chemical and biological molecules, they allow the generation of ‘smart’ nanoscale architectures; the assembly and function of these architectures are responsive to chemical or biological stimuli, in much the same way that biomaterials are made and function in cells. Co...
addition, gbM in plants may prevent aberrant transcription from internal cryptic promoters128. Indeed, in mouse cells, intragenic DNA methylation protects the gene body from spurious Pol II entry and cryptic transcription initiation129. It was also suggested that gbM increases pre-mRNA splicing ...
检测范围广:全基因组范围鉴定甲基化修饰区域l 针对性强:针对性检测基因组内具有甲基化修饰的区域l 成本低:大大降低了测序数据量,测序成本低研究案例:Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells 小鼠...
because the function of the mutated gene needs to be restored, not further disrupted. 因为这些变异基因的功能需要重置,而不是进一步打乱。 So cutting this already-mutated hemoglobin gene that causes sickle cell anemia won't restore the ability of patients to make healthy red blood cells. 因此,把那...