Requirement for phosphatidylinositol 3-kinase in epidermal growth factor-induced AP-1 transactivation and transformation in JB6 P+ cells. Phosphatidylinositol 3-kinase (PI 3-kinase) plays a role in a variety of biological processes, including regulation of gene expression, cell growth, and di... ...
As reported in the journalCellon Feb. 8, 2018, biologists Javier Lopez-Garrido, Kit Pogliano and their colleagues at UC San Diego and Imperial College in London found that DNA executes an unexpected architectural role in shaping the cells of bacteria. Studying the bacterium Bacillus subtilis, the...
According to the arrangement of repeating units, repeats can be classified into two types: tandem repeats (TRs) and interspersed repeats24, as depicted in Fig.1(b). Interspersed repeats, also known astransposonsorTEs, consist of DNA and RNA transposons25. Generally, TRs refer to a sequence arr...
Norwood TH, Gray M. The role of DNA damage in cellular aging: is it time for a reassessment? Exp Gerontol. 1996; 31(1-2):61-68. [PubMed: 8706805]Norwood, TH, Gray, M (1996) The role of DNA damage in cellularaging: is it time for a reassessment. Exp Gerontol 31: pp. 61-8...
Advances in our basic understanding of the nature of DNA damage, DNA repair mechanisms, and the response of eukaryotic cells to accumulated DNA damage provide a solid rationale for a reassessment of the causal role of the accumulation of chromosomal damage in cell senescence in vitro. 展开 关键...
Since the genus Sphingomonas contains known HCH degraders, the results suggest that the population detected was enriched in situ by HCH contamination and may play a role in HCH degradation. Recently, high-density 16S rRNA gene microarrays (PhyloChips) containing 500,000 probes have been developed ...
What role does the DNA polymerase I play in the leading strand vs. the lagging strand?Question:What role does the DNA polymerase I play in the leading strand vs. the lagging strand?DNA Replication:DNA replication is the process by which a cell's DNA is copied. Depending...
(TAPS), a less destructive approach than bisulphite sequencing, which permits the simultaneous analysis of genomic and methylomic data. We conduct a diagnostic accuracy study across multiple cancer types in symptomatic patients, achieving 94.9% sensitivity and 88.8% specificity. Matched tumour biopsies ...
3. F.K. Teixeira et al., “A role for RNAi in the selectivecorrectionof DNA methylation defects,”Science,323:1600-04, 2009. 4. M. Regulski et al., “The maize methylome influences mRNA splice sites and reveals widespread paramutation-like switches guided by small RNA,”Genome Res, ...
The ATP-dependent chromatin remodeller DDM1 has a vital role in plant DNA methylation, influencing gene silencing and suppression of transposable elements. The structure of DDM1 in complex with nucleosome in different states of the ATP hydrolysis process reveals the molecular mechanism underlying chroma...