Adams教授和梅奥医学中心的João F. Passos教授2021年10月28日在Cell上发表题为“Cytoplasmic DNA: sources, sensing, and role in aging and disease”的综述,重点介绍了细胞质DNA的形成及其相关功能的潜在分子机制,为寻找治疗慢性疾病的策略提供了新思路。 摘要 内源性细胞质DNA(endogenous cytoplasmic DNA, cytoDN...
2023年4月24日,上海市免疫学研究所叶菱秀团队与中科院分子细胞卓越中心孟飞龙团队在Cell期刊在线发表了题为“Mesoscale DNA Feature in Antibody-Coding Sequence Facilitates Somatic Hypermutation”的研究论文。该论文从生化、细胞和小鼠模型三...
无菌性炎症是导致慢性疾病及个体衰老的重要因素,最近研究发现细胞质DNA与无菌性炎症的激活途径有明显的相关性。桑福德伯纳姆普雷比医学研究所的PeterD. Adams教授和梅奥医学中心的João F. Passos教授2021年10月28日在Cell上发表题为“Cytoplasmic DNA: sources, ...
Cell(2013). doi:10.1016/j.cell.2013.02.023 4. Turner, K. M. et al.Extrachromosomal oncogene amplification drives tumour evolution and geneticheterogeneity. Nature 543, 122–125 (2017). 5. Sur, I. & Taipale, J.The role of enhancers in cancer. Nat. Rev. Cancer 16, 483–493(2016). ...
The Role of DNA Damage and Repair in Cell Aging: B.A. Gilchrest, V.A. Bohr (Eds.), Elsevier, Amsterdam, 2001, ISBN 0-444-50494-X, Price € 108.91, US$ 118Ontogenetic development of FMRFamide immunoreactivity in the cells and nerve fibers of the pituitary was studied in the tree ...
DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle. We determined whether DNA methylation plays a role in exercise-induced gene expression. Whole...
11. Setlow, R.B. and J.K. Setlow, Evidence that ultraviolet-induced thymine dimers in DNA cause biological damage. Proc Natl Acad Sci U S A, 1962. 48: p. 1250-7. 12. Setlow, J.K. and R.B. Setlow, Nature of Photoreactivable Ultra-Violet Lesion in Deoxyribonucleic Acid. Nature...
Modification of DNA's structure introduces diversity into this rather ubiquitous polymer, resulting in an expansion of both its informational content and functionality. It is clear that DNA base modifications play a role in distinguishing self from non-self, in protecting an organism's genome from ...
Hubei Provincial Research Center for Precision Medicine of Cancer Abstract: Radiotherapy plays an important role in the treatment of malignant tumors, and how to improve the radiosensitiv- ity of tumors is a major topic of clinical...
2022年8月22日,德国海德堡大学Daniela Mauceri在《Cells》杂志发表了“Role of Epigenetic Mechanisms in Chronic Pain”的综述文章,讨论了DNA甲基化、组蛋白修饰、非编码RNA等表观遗传机制对慢性疼痛的影响。 期刊:Cells 日期:2022.08....