Adams教授和梅奥医学中心的João F. Passos教授2021年10月28日在Cell上发表题为“Cytoplasmic DNA: sources, sensing, and role in aging and disease”的综述,重点介绍了细胞质DNA的形成及其相关功能的潜在分子机制,为寻找治疗慢性疾病的策略提供了新思路。 摘要 内源性细胞质DNA(endogenous cytoplasmic DNA, cytoDN...
The potential role of serial circulating tumor DNA (ctDNA) testing after upfront surgery to guide adjuvant chemotherapy for early stage pancreatic cancer: The AGITG DYNAMIC-Pancreas trial. Background:Recurrence rates following up...
无菌性炎症是导致慢性疾病及个体衰老的重要因素,最近研究发现细胞质DNA与无菌性炎症的激活途径有明显的相关性。桑福德伯纳姆普雷比医学研究所的PeterD. Adams教授和梅奥医学中心的João F. Passos教授2021年10月28日在Cell上发表题为“Cytoplasmic DNA: sources, s...
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DNA methylation is a covalent biochemical modification controlling chromatin structure and gene expression. Exercise elicits gene expression changes that trigger structural and metabolic adaptations in skeletal muscle. We determined whether DNA methylation plays a role in exercise-induced gene expression. Whole...
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