(Biochemistry) deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen ...
In literature, the terms cfDNA and exDNA are often used to define DNA outside the confinement of cells as opposed to intracellular DNA (inDNA). In contrast, the term eDNA is chiefly used to determine exDNA found in environmental samples such as sand, soil, or water. cfDNA and exDNA are...
in terms of the total energy in Joules imparted by the beta electron or alpha particle decays of the internal radionuclide contamination to one kilogram of tissue. For this calculation, the tissue is modelled as water. For example, those whose body contains 100 Bq of Strontium-90 are assessed...
swiftly phosphorylated at T68 by ATM in response to DNA damage68,69. Once phosphorylated, CHK2 undergoes autophosphorylation and dimerization, which leads to its full activation70. ATM and CHK2 target many shared and exclusive substrates that may amplify DDR signaling, further activating substrates an...
crime laboratories are now able to analyze targeted and relevant forensic markers to generate investigative leads and help determine the number of contributors in a mixture analysis. The application of NGS is particularly helpful with those degraded samples...
This work was also supported by the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging funded by NIH P30AG068635, NIH 1K99GM141482 and George E. Hewitt Foundation for Medical Research Postdoctoral Fellowship to L.E.N., Paul F. Glenn Foundation for Medical Research ...
Collect the Full Set There’s so much to be learned about our ancestors. I“collect”Y-DNAhaplogroups from testers in each of my ancestral lines to reveal their history that has been obscured by time – and to assure my recent genealogy is accurate. ...
Note:The terms polymorphism and mutation in this sense do not refer to anything medical. Population A population is a group of people who inhabit a geographic region or share a common origin. Population Bottleneck A population bottleneck is when a population is greatly reduced in size. ...
As is stands today the whole human genome can be included in one microarray. However, there are still unmet needs in terms of analysis of the variation occurring in the human genome and how this may alter cellular behavior in relation to physiological and disease processes. The development of ...
The enriched terms are ranked by -log10 (p values). n = 1. b, c, Western blot of p-ATR, p-CHK1 and γH2A.X in NUFIP1 knockdown (b) and knockout (c) HeLa cells. Cells were treated with 2 mM HU. n = 3 independent experiments. d, e, Representative IHC images ...