Since the initial discovery, over a decade and a half ago, that genetically engineered DNA can be delivered in vaccine form and can elicit an immune response, there has been a great deal of progress in understanding the basic biology of this platform. Data from preclinical studies using DNA ...
M. Self-assembled monolayers of thiolates on metals as a form of nanotechnology. Chem. Rev. 105, 1103–1170 (2005). Article CAS Google Scholar Dreyfus, R. et al. Aggregation-disaggregation transition of DNA-coated colloids: experiments and theory. Phys. Rev. E Stat. Nonlin. Soft Matter ...
The whole-genome sequence (WGS) refers to the full genomic DNA sequence (Mancia, 2018). Considerable progress has been made in WGS since the first entire bacterial genome (Haemophilus influenzae) was sequenced by the Sanger DNA sequencing method (Land et al., 2015). Currently, the next-...
Murray DC, Pearson SG, Fullagar R, Chase BM, Houston J, Atchison J, White NE, Bellgard MI, Clarke E, Macphail M, Gilbert MTP, Haile J, Bunce M (2012). High- throughput sequencing of ancient plant and mammal DNA preserved in herbivore middens. Quaternary Science Re- views, 58, 135...
Full size image Given that immune cells express high levels of TLR9 and are also a source of circulating, cell-free DNA35, we also examined whether bloodborne infiltrating cells and DNA from extracellular sources might contribute to the observed up-regulation of TLR9 signalling and memory. Such ...
DNA Repair publishes full-length research articles, brief reports on research, and reviews. Reviews require an approval by the Editors-in-Chief prior to submission. The journal also welcomes articles describing databases, methods and new technologies supporting research on DNA repair and responses to ...
Full size image We also analyzed these CRISPR/Cas9-induced primary liver tumor cells for micronucleus formation, which is frequently involved in chromosomal aberrations and genomic instability in cancer [53]. Micronucleus formation was readily detected in these tumor cells (Fig. 6C). The percentages ...
Download: Download full-size image Figure 2. mPTP opening and VDAC oligomerization enable mtDNA cytosolic release and NLRP3 inflammasome activation (A) VDAC oligomerization in BMDM that were pretreated ± VBIT-4 (10 μM, 16 h), primed ± LPS (200 ng/mL, 4 h), and stimulated ± ATP (4...
Deployment of some form of intrusion detection is essential in high-security environments, consistent with the "prevent, detect, and react" approach to security discussed in the "Security, Introduction" section. IDS sensors should be placed on every distinct network, even in front of a firewall ...
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall-Hreidarsson syndrome. Clin. Genet. 84, 210 (2013). CAS PubMed Google Scholar Walne, A. J., Vulliamy, T., Kirwan, M., Plagnol, V. & Dokal, I. Constitutional mutations in RTE...