(Biochemistry) deoxyribonucleic acid; a nucleic acid that is the main constituent of the chromosomes of all organisms (except some viruses). The DNA molecule consists of two polynucleotide chains in the form of a double helix, containing phosphate and the sugar deoxyribose and linked by hydrogen ...
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease. Science 366, 1531–1536 (2019). Article CAS PubMed PubMed Central ADS Google Scholar Soubannier, V. et al. A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr. Biol....
Full size image Optimization of transcriptional elements. Several laboratories have identified methods to optimize the transcriptional elements in the plasmid backbone so that gene transcription and expression can be improved. An important component of the plasmid is the promoter that drives expression of ...
Murray DC, Pearson SG, Fullagar R, Chase BM, Houston J, Atchison J, White NE, Bellgard MI, Clarke E, Macphail M, Gilbert MTP, Haile J, Bunce M (2012). High- throughput sequencing of ancient plant and mammal DNA preserved in herbivore middens. Quaternary Science Re- views, 58, 135...
rather than the degradation in lysosomes.4Sphingomyelinase catalyzes the conversion of sphingomyelin to ceramide and phosphorylcholine. Ceramide enriched endosomes tend to form inward buds ending in ILV formation Full size image Box 1: Terminology...
Full size image The stable active marks or the repressive mark H3K27me3 inmddccand the wild type exhibited the highest peak intensities, whereas the variable marks, especially those lost in the mutant, displayed low peak intensities (Fig.4g). Newly gained active marks as well as H3K27me3...
found that γ-H2AX foci form preferentially in euchromatin but not in heterochromatin after exposure to ionizing radiation [59]. In S phase, EDSBs are still hypermethylated, albeit less significantly than in the G0 phase [1]. Because DNA replication does not occur simultaneously throughout the ...
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Full size image Discussion In this study we set to better understand the formation of RNA:DNA hybrids at DSBs as well as the potential function of RNA:DNA hybrids removal factors in DSB repair, focusing on senataxin, a well characterized R-loops helicase. We discovered that senataxin is specif...
[44]. Filled circles – results for the full force field, empty circles – an estimate based on the number of native contacts. Full size image Such results indicate that the correlation to experimental binding free energy is generally a poor measure of force field performance, in line with ...