e-Design: Computer-Aided Engineering Design (Academic, 2016). Olson, G. B. Computational design of hierarchically structured materials. Science 277, 1237–1242 (1997). Article CAS Google Scholar Panchal, J. H., Kalidindi, S. R. & McDowell, D. L. Key computational modeling issues in ...
Since the initial discovery, over a decade and a half ago, that genetically engineered DNA can be delivered in vaccine form and can elicit an immune response, there has been a great deal of progress in understanding the basic biology of this platform. Data from preclinical studies using DNA ...
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Sign in to download full-size image Figure 2.Microarray. Nucleic acid microarrays must first be produced by eitherin situsynthesis or by robotic deposition of nucleic acids. Forin situsynthesis, multiple probes per gene are placed on the array, while in the case of robotic deposition longer (...
Sign in to download full-size image FIGURE 9.14.The Sanger method for sequencing DNA. With the automation ofDNA sequencingin the 1980s, new methods have produced equipment that have been very effective in more rapidly sequencing DNA. Much research and development has continued to be directed towa...
-2, respectively full size image in fig. 1 , a single value is assigned for matches and mismatches (+1 and −1 in the example) regardless of the parts involved. this works well with nucleotides (dna or rna sequences) but not for proteins. during evolution, some combinations are more ...
In 2006, researchers from the California Institute of Technology introducedenzyme-free logic computing(opens in new tab), which has since become the go-to approach for programming chemical reaction networks among computer scientists. Because of its simplicity and tunability, TMSD in particular...
DNA storage is a new digital data storage technology based on specific encoding and decoding methods between 0 and 1 binary codes of digital data and A-T-C-G quaternary codes of DNAs, which and is expected to develop into a major data storage form in the future due to its advantages (...
contributing tohuman disease. Coincident with the completion of these two projects and with the development of computer databases capable of storing the full human genome sequence and known variations camegenome-wide association studies, aimed at identifying associations between thevariantsand particular ...
Full size image Figure 2 FAIRE-seq coverage and functional window for aP. falciparumgene. Each box shows FAIRE-seq coverage (black) of the region at a given time point (0 h to 36 h with six hours increments). The functional window with the highest variance of FAIRE-seq is shown in lig...