Now, there is deep interest in identifying free radical scavengers or antioxidants that inhibit oxidative DNA damage. This review describes all the possible mechanisms of DNA damage and repair in general and recent progress in plants.S. Yadav...
Scientists have known for some time that amaster genenamed SOG1 acts like a general contractor for repair, coordinating with various genetic subcontractors of the plant cell to mount an effective DNA damage response. But, it wasn't clear which specific genes were among the subcontractors, nor ho...
In comparison with other eucaryotic systems, our understanding of the repair of ultraviolet light-induced DNA damage in plants is still rather limited. Morphological features and pigments afford considerable protection and attenuate the dose of ultraviolet light reaching the plant cell DNA. Nevertheless,...
DNA损伤与修复机制 | DNA damage and repair DNA损伤修复功能异常是肿瘤发生发展的重要特点之一,突变与癌症的发生均包含细胞DNA损伤过程。人类细胞中的DNA每天都会由于外部(外源)和内部(内源)的代谢进程而遭受成千上百次损伤。细胞基因组的改变可能导致DNA转录过程出现错误,进而通过翻译过程影响到信号转导和细胞功能必需...
Chapter5 DNAdamage,repairandmutation 第一节DNA损伤 一、自发性损伤（spontaneousmutations）1、DNA复制错误校正后的错配率仍约在10-10左右2、互变异构(烯醇式-酮式结构互变)3、自发性的化学变化脱嘌呤和脱嘧啶脱氨（基）(deamination)作用 （1）脱嘌呤和脱嘧啶 •糖苷键断裂,嘌呤和嘧啶从DNA链的核糖磷酸骨架...
10.5DNA损伤与修复 DNA Damage and Repair 这门课程主要包括四个方面的内容:1、生物大分子的结构与功能:包括蛋白质、核酸、酶、聚糖等的分子组成,分子结构,结构与功能的关系及主要理化性质。2、物质代谢及其调节:包括糖、脂质、氨基酸、核苷酸、非营养物质代谢及物质代
& Yan S. (2018) Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair. PNAS 115, E3837–E3845.5. Li C., Guo Y., Wang L. & Yan S. (2023) The SMC5 / 6 complex recruits the PAF1 complex to facilitate DNA double-strand break repair in Ar...
[35]Yan S, Sorrell M, Berman Z. Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress[J]. Cell Mol Life Sci, 2014, 71(20): 3951-3967. DOI: 10.1007/s00018-014-1666-4. [3...
&Yan S. (2018) Negative regulator of E2F transcription factors links cell cycle checkpoint and DNA damage repair.PNAS115, E3837–E3845. 5. Li C., Guo Y., Wang L. &Yan S. (2023) The SMC5 / 6 complex recruits the PAF1 complex to facilitate DNA double-strand break repair in ...
DNA damage is an abnormal chemical structure in DNA which can cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA mo...