8. Qin G, Liu Z, Yang J, et al. Targeting specific DNA G-quadruplexes with CRISPR-guided G-quadruplex-binding proteins and ligands[J]. Nature Cell Biology, 2024: 1-13. 9. Zhang R, Shu H, Wang Y, et al. G-quadruplex structures are key modulators of somatic structural variants in ...
The HTH domain is widely used by both prokaryotes and eukaryotes whereas the HLH motif is found mostly in eukaryotes. For example, the HTH motif is found in the Crp global activator ofE. coliand in both the CI and Cro regulatory proteins of bacteriophage lambda. Eukaryotic transcription factors...
1.1.2 Single stranded DNA-binding protein (SSB) The single stranded DNA-binding protein (SSB) is an important protein that participates in replication, repair and recombination machineries in all prokaryotes. Although this family of proteins share little sequence similarity across phylogenetically diverse...
Many cellular functions rely on DNA-binding proteins finding and associating to specific sites in the genome. Yet the mechanisms underlying the target search remain poorly understood, especially in the case of the highly organized mammalian cell nucleus. Using as a model Tet repressors (TetRs) sea...
The proteins of replication forks of eukaryotes and prokaryotes are also different, but the corresponding parallel relationship can be found, as summarized in the figure below. Fig. 13 Comparison of replication forks between prokaryotes and eukaryotes ...
In prokaryotes, control of DNA replication and related processes for cell division are aided by a family of DNA-binding proteins known as nucleoid-associated proteins (NAPs)1. GapR is an essential NAP in Caulobacter crescentus involved in DNA replication, chromosome segregation and cell division2,3...
On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 stru
Tanaka I, Appelt K, Dijk J, White SW, Wilson KS (1984) 3-Å resolution structure of a protein with histone-like properties in prokaryotes. Nature 310:376–381 CrossRef About this Chapter Title DNA-Binding Proteins and Their Interactions with Structure-Building Ions Book Title Bacterial Ch...
for all life forms. Eukaryotic genomes, organized into multiple linear chromosomes of different sizes, present a very complex and intricate framework for DNA replication regulation compared to prokaryotes. A single bidirectional replication origin is sufficient to direct all DNA synthesis in prokaryotes. ...
present a very complex and intricate framework for DNA replication regulation compared to prokaryotes. A single bidirectional replication origin is sufficient to direct all DNA synthesis in prokaryotes. In contrast, eukaryotic chro...