The binding specificities of RNA- and DNA-binding proteins are determined from experimental data using a ‘deep learning’ approach. Knowing the sequence specificities of DNA- and RNA-binding proteins is essential for developing models of the regulatory
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The enzyme reverse transcriptase synthesizes a DNA chain on an RNA template, and DNA polymerase converts the single-stranded DNA molecules into double-stranded DNA molecules that can further be used as templates (Figure 9.2, top). Then a PCR reaction is run to amplify a fragment of DNA to ...
英文名称:Southern DNA Marker DL2000(Labeled by Biotin) 货号:LM-120654C 保存条件:4℃保存 Southern DNA Marker DL2000(生物素标记)常见的DNA与RNA提取方法 第一部分:基因组DNA的提取及常见的问题 第二部分: RNA的提取及常见的问题 基因组DNA的用途: ...
35,42,43 This appears to be at least partially due to decreased leakage of proteins such as DNA and RNA polymerases from the nucleus during isolation as the heat-denatured proteins become aggregated and thus insoluble. This phenomenon is referred to as heat-induced nuclear protein aggregation. ...
and increased dramatically inatm, to a much higher level (Fig.1c). To further dissect genome-wide R-loop changes in response to CPT treatment, we performed ssDRIP-seq (a single-stranded DNA ligation-based library construction from DNA:RNA hybrid immunoprecipitation, followed by sequencing)34,35...
The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for ...
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5a). RNA-seq analysis of NT embryos indicated that cloned embryos have effectively reset their transcriptional landscape, including activation of zygotic genome activation genes and importantly, also, of ‘reprogramming resistant regions’ (RRRs)31 (Fig. 5b,c and Extended Data Fig. 7h,i). Thus,...
as observed in qPCR, correlated with the RNAseq data. Figure 2 Integrative analysis of genes with differentially methylated promoters and differential expression and qPCR analysis of selected genes in brain tissues resected from FCD type II patients. (A,B) Venn diagram showing total number of ...