Sciatic nerves of 8 M Dmd(mdx) rats had more consistently increased levels of S100 beta and Tau5 proteins, compared with 9 M mdx mice, supporting pronounced dystropathology in the rat model. There were no differences for mRNA levels, apart from higher gelsolin mRNA in Dmd(mdx) sciatic ...
Objective: The purpose of this preclinical study is to evaluate the myocardial efficacy and safety of intended commercial process delandistrogene moxeparvovec (SRP-9001) material in Duchenne muscular dystrophy (DMD)mdx rats. DMDmdx rats are a valuable alternative animal model of DMD, as they ...
We quantified levels of 8 proteins (by immunoblotting) in sciatic and radial nerves from young adult Dmdmdx rats (aged 8M) and mdx mice (9M), plus levels of 7 mRNAs (by qPCR) in rat nerves only. Sciatic nerves of 8M Dmdmdx rats had more consistently increased levels of S100尾 and ...
Dmdmdx rats are characterized by muscle weakness and by a decrease in a spontaneous activity.Thibaut LarcherAude LafouxLaurent TessonSéverine RemyVirginie ThepenierVirginie FrançoisCaroline Le GuinerHelicia GoubinMaéva DutilleulLydie Guigand
No dystrophin expression was detected in cardiac and skeletal muscles of Dmdmdx rats.Thibaut, Larcher