et al. Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells. Nature 620, 651–659 (2023). https://doi.org/10.1038/s41586-023-06342-8 Download citation Received30 December 2021 Accepted19 June 2023 Published19 July 2023 Issue Date17 August 2023 DOIhttps://doi.org/...
The diversity of resistant types as a result of the variability in intrinsic cell states may be a generic feature of responses to external cues.#Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a ...
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells 药物使用,包括种类、剂量、给药方式,对耐药性的呈现(不是产生)有巨大的影响。 肿瘤耐药性的产生,不单纯依赖基因背景的。...
‘crashed’ the clonal population with a targeted therapy to reveal a small subpopulation of persisters, some of which eventually gained the ability to proliferate in drug. Finally, to avoid growth competition, we expanded surviving colonies in isolation from one another in drug over the course of...
Virulence in clonal plants: Conflicting selection pressures at work? Evol. Ecol. 2007, 22, 467–470. [Google Scholar] [CrossRef] [Green Version] Garcia-Arenal, F.; Zerbini, F.M. Life on the Edge: Geminiviruses at the Interface between Crops and Wild Plant Hosts. Annu. Rev. Virol. ...