et al. Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells. Nature 620, 651–659 (2023). https://doi.org/10.1038/s41586-023-06342-8 Download citation Received30 December 2021 Accepted19 June 2023 Published19 July 2023 Issue Date17 August 2023 DOIhttps://doi.org/...
The diversity of resistant types as a result of the variability in intrinsic cell states may be a generic feature of responses to external cues.#Anti-cancer treatment often results in a subset of the clonal cell population developing resistance to therapy, with resistant cells displaying a ...
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells 药物使用,包括种类、剂量、给药方式,对耐药性的呈现(不是产生)有巨大的影响。 肿瘤耐药性的产生,不单纯依赖基因背景的。...
Generation of clonal cell line PC9-1 in erlotinib-free media We made use of the ‘EGFR-addicted’ NSCLC cell line PC9 acquired from the Minna Laboratory at UT Southwestern; single-nucleotide polymorphism cell line fingerprinting was performed to confirm the cell identity. Overall, 10,000 PC9 cel...
PCs emerge at multiple GC maturation stages as expanded “nodes” We interrogated PC differentiation within clonal lineages, with examples from Ms#1 (Figure 3A) and Ms#5 (Figure S3A) plotted (clones identifiable by Roman numerals in Figure 2D). GC maturation trajectories were followed using infer...