The dissolution data were further characterized using model-independent parameters DP 30 , DE 50 , t 50% , similarity factor f2 and difference factor f1 . The tablets formulated incorporating the AC: PEG 6000 (1:2) binary system displayed significantly improved dissolution profile as compared to ...
Dissolution results of all the tablet formulations and the innovator brand were further analyzed with difference factor (f1), similarity factor (f2), dissolution efficiency and dunnet,s test. These results indicated that all generic ciprofloxacin tablets included in this investigation were bioequivalent ...
Methods: The assay and dissolution tests were performed according to the methods described in the United States Pharmacopoeia. The dissolution profiles of the medicines were compared using the independent model approach with a s...
To demonstrate the usefulness of the proposed system, the dissolution profiles of different lots of HCT-BIS tablets were acquired and three of them were conveniently compared at a 31 data point level, employing the f1 and f2 ("difference" and "similarity") indexes. Use of multiple data points...
Other release parameters, such as dissolution time (tx%), assay time (tx min), dissolution efficacy (ED), difference factor (f1), similarity factor (f2) and Rescigno index (ξ1 and ξ2) can be used to characterize drug dissolution/release profiles.Paulo Costa and José Manuel Sousa Lobo...
The results of the difference factor (f1) and similarity factor (f2), as well as the paired t-test, for the parameters of the fitted equations indicated that there was no difference between the measured and predicted values of dissolution profiles of the validation set samples. In summary, ...
With demonstrated acceptable intra﹍ot variability, data were analyzed using f1 (difference factor) and f2 (similarity factor) procedures. The generic monensin products did not demonstrate similar in vitro dissolution profiles to the pioneer product in these USP biorelevant media. Differences in physical...
The ratio test includes percentage, area under the curve, mean dissolution time, while the pair wise procedure includes difference factor (f1), similarity factor (f2), and Rescigno index. In the model-dependent approach, zero order, first order, Hixson-Crowell, Higuchi, and Weibull models were...
The established models were validated with a test set, and the difference factor f1 and the similarity factor f2 between the measured and predicted curves were calculated to evaluate the prediction accuracy. The prediction results of the BP-ANN and PLSR models were compared with the measured ...
To establish the in-vitro and in-vivo correlation concepts the difference factor F1 and the similarity factor F2 has calculated against innovator sample. The multimedia dissolution at various time points were carried out in different pH such as pH 1.2,4.5,6.8,7.0 and 7.4 to match with inno...