Consequently, ␣-L-iduronidase deficiency results in a disease that involves multiple organ systems resulting from the accu- mulation of undegradable GAG material throughout the body. The population frequency of MPS I is estimated to be approx- imately 1 in 100,000 births, with MPS I-H ...
extracellular regulated protein kinases (ERK)/protein kinase B (Akt), mitogen-activated protein kinase (MAPK), signal transducers and activators of transcription (STAT)-1] that affect the cells, tissue, and system after PM exposure, and the binding of pathogenic antibodies to pro-inflammatory cell...
Rare diseases refer to medical conditions that affect a very small number of individuals. They are characterized by a wide diversity of disorders and symptoms, which can vary not only from disease to disease but also among individuals suffering from the same condition. Approximately 80% of these ...
(T3SS). The precise mechanism underpinning NLRP1 activation remains elusive, with insights primarily derived from mouse studies.6,104In contrast to humans that have only one NLRP1 gene, mice express multiple NLRP1 alleles, with NLRP1B being the main subject of study.104NLRP1 is capable of ...
In addition to the vesicle-dependent pattern, a considerable number of extracellular ncRNAs are present in the form of ribonucleoprotein (RNP) complexes with RNA-binding proteins (RBPs) such as argonaute-2 (AGO2) that modulate mRNA inhibition in cells.120,121 These RBPs can affect RNA sorting...
Rheumatoid arthritis (RA) is an autoimmune disease characterized by symmetrical, polyarticular inflammation of small joints. The pathogenesis of RA remains unclear, and it can affect multiple organ systems [210]. Autoimmune reactions and inflammation are the primary mechanisms involved, encompassing variou...
In fact, that environmental pollutants can affect multiple organ systems is not a new topic in chronic disease research. And oxidative stress, systemic inflammation, and autonomic imbalance were usually widely accepted mechanisms [63, 64]. Previous studies have reported that exposure to environmental ...
although with manifestations more marked in the cell tissues in which it is most expressed and needed, as demonstrated by the many chaperonopathies studied that affect predominantly, but not exclusively, the central or peripheral nervous systems, or the muscular system, or the cardio-circulatory app...
(T3SS). The precise mechanism underpinning NLRP1 activation remains elusive, with insights primarily derived from mouse studies.6,104In contrast to humans that have only one NLRP1 gene, mice express multiple NLRP1 alleles, with NLRP1B being the main subject of study.104NLRP1 is capable of ...
These are just examples of common autoimmune diseases, and there are many other autoimmune diseases that can affect various organs and systems in the body. Autoimmune diseases can be challenging to diagnose and manage, and treatment often involves a combination of medications to suppress the immune ...