The thalassemias are a group of inherited disorders of hemoglobin synthesis that continue to pause a global public health concern. The complex molecular and pathogenetic pathways involved in disease process lead to an array of comorbidities that require lifelong management. The disease and its treatment...
whereas osteoblasts produce new bone tissue. To maintain bone integrity, this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts...
reactivity, thereby increasing the risk of thrombotic events through the production of TMAO.175It has also been demonstrated that plasma or serum levels of TMAO can serve as a predictive factor for the formation of thrombosis formation.175,176Nemet et al. demonstrated that phenylacetylglutamine (PAG...
whereas osteoblasts produce new bone tissue. To maintain bone integrity, this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts...
Genetic variants among host guinea pigs may affect predisposition to infection and clinical signs (Van Hoosier and Robinette, 1976). Clinical signs include depression, lameness in one or more limbs, flaccid paralysis, weight loss, and death over 2 weeks. Hansen et al. (1997) reported that ...
Thus, one of the consequences of thousands of years of human co-existence with the malaria pathogen is that inherited red blood cell disorders known as sickle cell disease are maintained as a result of balancing selection.61 Sickle cell disease is a painful disease caused by abnormal hemoglobin ...
The BB305 lentiviral vector was employed to transduce modified β-globin genes into hematopoietic stem cells, resulting in the production of HbAT87Q—a hemoglobin variant that is resistant to disease and capable of inhibiting sickle hemoglobin polymerization. The remaining steps remain consistent with ...
Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological proc
These receptors, in turn, can activate NF kB and AP-1 transcription factors, inducing the production of NO, ROS, pro-inflammatory cytokines TNF α, IL-1 β, and IL-6, which may ultimately promote neuronal death [43]. There is a growing evidence that perivascular macrophages (PVMs), the...
Because of its glucose-dependent mode of action, vildagliptin has a reduced risk of hypoglycemia, which eliminates the “defensive eating” that can emerge with insulin injections or independent glucose-insulin secretagogues. More data show that vildagliptin may affect postprandial lipid and lipoprotein...