The thalassemias are a group of inherited disorders of hemoglobin synthesis that continue to pause a global public health concern. The complex molecular and pathogenetic pathways involved in disease process lead
substantial proportion of loci remaining altered after the diet returns to normal. These long-lasting chromatin accessibility changes were discovered to be correlated to specific transcription factors as well as histone modifications, indicating that long-term risk of metabolic diseases may be impacted by...
whereas osteoblasts produce new bone tissue. To maintain bone integrity, this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts...
Gibson TJ, Murphy RM (2005) Design of peptidyl compounds that affect β-amyloid aggregation: importance of surface tension and context. Biochemistry 44:8898–8907 PubMed CAS Google Scholar Gibson G, El-Agnaf OM, Anwar Z, Sidera C, Isbister A, Austen BM (2005) Structure and neurotoxicity...
Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological proc
Genetic variants among host guinea pigs may affect predisposition to infection and clinical signs (Van Hoosier and Robinette, 1976). Clinical signs include depression, lameness in one or more limbs, flaccid paralysis, weight loss, and death over 2 weeks. Hansen et al. (1997) reported that ...
this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts the delicate balance between bone production and resorption and accelerates bone loss, suggesting that optimal ...
The BB305 lentiviral vector was employed to transduce modified β-globin genes into hematopoietic stem cells, resulting in the production of HbAT87Q—a hemoglobin variant that is resistant to disease and capable of inhibiting sickle hemoglobin polymerization. The remaining steps remain consistent with ...
These receptors, in turn, can activate NF kB and AP-1 transcription factors, inducing the production of NO, ROS, pro-inflammatory cytokines TNF α, IL-1 β, and IL-6, which may ultimately promote neuronal death [43]. There is a growing evidence that perivascular macrophages (PVMs), the...
Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplement