Brucellosis is a bacterial infection that can affect goats and other livestock such as sheep and cows and wild ruminants such as deer, elk and bison. Brucellosis causes abortion or stillbirth in animals. Brucellosis is one of the widest spread zoonosis transmitted by animals and in endemic areas...
whereas osteoblasts produce new bone tissue. To maintain bone integrity, this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts...
have suggested that the presence of gut microbes may directly contribute to platelet hyperreactivity, thereby increasing the risk of thrombotic events through the production of TMAO.175 It has also been demonstrated that plasma or serum levels of TMAO can serve as a predictive factor for the ...
In the last few years, the integrity of the intestinal barrier has been aggressively investigated in sickle cell disease (SCD), a genetic disorder of mutation, that results from a mutation of the β-globin gene, and renders the sickle hemoglobin (HbS) to polymerization upon deoxygenation, promot...
this process must be tightly regulated. Increasing evidence indicates that both iron overload and deficiency affect osteoclast and osteoblast differentiation and activity in a manner that disrupts the delicate balance between bone production and resorption and accelerates bone loss, suggesting that optimal ...
Ocular diseases are closely related to the physiological changes in the eye sphere and its contents. Using biomechanical methods to explore the relationship between the structure and function of ocular tissue is beneficial to reveal the pathological proc
Several experimental and clinical studies have presented convincing findings supporting the correlation between DNA methylation and the persistence of metabolic memory. Previous investigations have demonstrated that environment factors and dietary choices may affect epigenetic modifications, there contributing to in...
Furthermore, the uneven distribution of biomimetic nanoparticles represents another limitation of ultrasonic preparation, as it can lead to localized high temperatures that affect the activity of membrane proteins [53]. With the advancement of microcurrent technology, electroporation technology based on ...
The primary limitation of brain delivery is whether the vector distribution is sufficiently broad to encompass all affected brain regions. For example, CSF delivery typically leads to the transduction of a small number of neurons in the putamen, while intraputaminal injections do not affect cells in...
ii) halt the production of abnormal deleterious protein while leaving all other proteins unaffected; iii) increase the synthesis of a protein of interest; iv) hide non-sense mutation on the mRNA that prevent the production of a complete protein or correct mutations that affect mRNA splicing. Depe...