Fetal Hemoglobin Levels in Patients With Sickle Cell Disorders and its Correlation With Disease SeverityResults: 100 patients had sickle cell disease and 138 had sickle cell trait. The mean age of presentation was higher in AS patients (24.89± 7.1 years) as compared to SS patients (22.22±7.9...
Morphologic changes may also be present that may give clues as to the cause of the anemia. Blood parasites and Heinz bodies may be seen on a blood smear. Because of the small size of feline erythrocytes, recognizing spherocytes in this species is difficult and is best left to an ...
A novel finding is that high levels of TGs and low HDL-C were associated with increased risk of anxiety and stress-related disorders. Additionally, we found that individuals with depression, anxiety, or stress-related disorders demonstrated higher levels of TGs and TC already 20 years before ...
Hematological studies of sickle cell anemia revealed that a variation in hemoglobin at the molecular level can be the underlying cause of disease. Simultaneous advances in techniques of protein and enzyme chemistry permitted recognition of a large number of other genetic disorders of hemoglobin synthesis...
Insulin resistance is a characteristic that causes the body to react to insulin less effectively. Rising blood glucose levels prevent insulin from working properly, which leads to the release of more insulin. This may cause the pancreas to gradually wear out in some type 2 diabetic people, which...
Aberrations in oxygen levels can often lead to pathological states, and hypoxia is a primary cause of clinical impairment in stroke and traumatic brain injury [1,3]. Processes that are characterized by alterations in oxygen metabolism and redox signaling can be the primary causes of neurological ...
There is no treatment for high hemoglobin as such - it's the underlying cause that needs to be treated. That is why getting to the bottom of the reason for these raised hemoglobin levels is so important. Was this caught during a routine blood test, or was your brother's doctor looking...
The term 'common disorder' is used for disorders that individually have a high impact on public health. Examples of common disorders include cardiovascular disease (CVD), stroke, diabetes, cancer, dementia, and depression. For a health-care practitioner – unlike a geneticist or an epidemiologist ...
Recent research found that risk of death is increased in patients with anemia which is dialysis related when levels of hemoglobin are persistently low during several months.
Over a thousand diseases are caused by mutations that alter gene expression levels. The potential of nuclease-deficient zinc fingers, TALEs or CRISPR fusion systems to treat these diseases by modulating gene expression has recently emerged. These systems can be applied to modify the activity of gene...