Researchers say that many of thedisease / diseasesthat are making a comeback are bothprevented / preventableand treatable. One big problem in England is that TB is affectingolden / oldpeople who have malnutrition – they do not have enough to eat. The number of elderly who have to gowithout...
Using reported parental disease history to decipher the genetics of Alzheimer’s disease may be promising, but this approach is also susceptible to complex selection and information bias that can mislead researchers if not accounted for. Emil M. Pedersen Theresa Wimberley Bjarni J. Vilhjálmsson Ne...
Machine learning models showed that social disparities, cardiometabolic disease and mental health were the main predictors of aging in Latin American populations, with these factors being more pronounced in low- and middle-income compared to high-income Latin American countries. Hernando Santamaria-Garcia...
Multiple sclerosis , Amyotrophic lateral sclerosis (MS,ALS)EAE allergic encephalomyelitis model (EAE)Mouse Cuprizone-induced demyelination of brain tissueMouse Pulmonary inflammation and fibrosisPulmonary inflammation model (LPS induction)Mouse/Rat Systemic inflammation model (LPS induction)Mouse/Rat ...
Riluzole, a treatment for amyotrophic lateral sclerosis (ALS), has been shown to be an effective pretreatment that sensitizes glioma to radiation therapy. It also has synergistic effects in combination with select other drugs when used to treat GBM. [62] Cannabidiol, another ALS treatment, ...
Summary The ALS/parkinsonism-dementia complex (PDC) of Kii is an endemic disease with a diverse phenotypic expression characteristic of classical ALS, parkinsonism and dementia. Its clinical and neuropathological manifestations are similar to a syndrome found in Guam, sharing classical ALS pathology to...
(2017) dismissed the hypothesis that chronic exposure to β-N-methylamino-L-alanine (BMAA) may be a risk factor for progressive neurodegenerative disease. They question the growing scientific literature that suggests the following: (1) BMAA exposure causes ALS/PDC among the indigenous Chamorro ...
Disease-modifying drugs for rare genetic disorders Rationale underlying nucleic acid-based drugs Nucleic acid therapeutics open almost infinite possibilities. They can be designed to i) restore the normal biological functions of deficient proteins; ii) halt the production of abnormal deleterious protein wh...
Although many perturbations in autophagy have been identified, it remains largely unclear how this contributes to disease pathogenesis and progression. Induction of autophagy can be protective in models of neurodegenerative diseases. Thus, understanding how autophagy is affected in these diseases is vital ...
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