To test this, the researchers first used a mousemodelin which the animal's own microglia could be removed. This led to a rapid influx of monocytes into thebrainand spinal cord, which gave rise to new microglia-like cells, and the mice displayed no pathological symptoms. But when the researc...
For instance, the second example is a typical question that requires multiple steps of reasoning over three evidences, where from the symptoms and signs we can know that this patient is highly likely an ALS case by looking at the evidence 1 and 2. Afterwards, from evidence 3, we know that...
(α-syn), but display heterogeneous clinical and pathological phenotypes. The mechanism underlying this heterogeneity is thought to be due to diversity in the α-syn strains present across the diseases. α-syn obtained from the post-mortem brain of patients who lived with these conditions is ...
et al. Telomere shortening leads to earlier age of onset in ALS mice. Aging 8, 382–393 (2016). CAS Google Scholar Kota, L. N. et al. Reduced telomere length in neurodegenerative disorders may suggest shared biology. J. Neuropsychiatry Clin. Neurosci. 27, e92–e96 (2015). PubMed ...
Haemangioblastoma is the archetypal vascular neoplasm of the central nervous system (CNS). Cytologically benign, it may occur either as a single lesions or as a multicentric tumour, as a sporadic case or as a familial disease. It constitutes the retinal
Alzheimer disease (AD) is the most common contributor to dementia in the world, but strategies that slow or prevent its clinical progression have largely remained elusive, until recently. This Review highlights the latest advances in biomarker technologi
diagnosis of ALS. Different combination of LMN and UMN signs can be observed. Limb onset is found in around 65 % of patients but most patients will develop signs in both bulbar region and limbs within the course of disease. Up to 50 % of ALS patients may have symptoms of Fronto-Temporal...
ALS is also a very complex disease. It's the only neurodegenerative disease that affects both the central and peripheral nervous systems. One might think it would be easy to diagnose, but it is not because the symptoms vary depending on which motor neuron is affected, and the disease progress...
Amyotrophic Lateral Sclerosis (ALS) Amyotrophic lateral sclerosis (ALS) is the most common form of adult motor neuron disease. As first described by the French neurologist, Charcot, in 1869, the primary symptom of disease is linked to the premature death of upper and lower motor neurons starting...
We hence provided a clinical description containing the main clinical symptoms, the time to onset after vaccination, the different therapeutic strategies adopted and the evolution after treatment. We also sought to better characterize the risk of occurrence of this rare but serious adverse event after...