The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The
Diseases like Alzheimer's and Parkinson's disease, Huntington's disease, Creutzfeldt鈥揓akob disease, cystic fibrosis, Gaucher's disease, Uremia as well as other neurodegenerative disorders, heart disease, some cancers, stroke (Chaudhuri & Paul,2006) are caused by inappropriate synthesis of protein....
Investigations of genetic diseases such as cystic fibrosis, alpha-1-antitrypsin deficiency, phenylketonuria, mitochondrial acyl-CoA dehydrogenase deficienc... P Bross,TJ Corydon,BS Andresen,... - 《Human Mutation》 被引量: 491发表: 1999年 Multidrug resistance proteins (MRPs/ABCCs) in cancer chemoth...
Other intraperitoneal infections, such as a PID-like tubal infection, have been reported.128 Female genital schistosomiasis has been coincidentally found with gynecologic cancers. However, no cause-and-effect relationship seems to exist. Diagnosis Since schistosomiasis is a geographically restricte...
A new technology developed at the University of Toronto is revealing biochemical processes responsible for diseases such as cystic fibrosis and could one day pave the way for pharmaceutical applications.
In addition, the uptake of PUFAs and antioxidants like Vitamin E from the diet are closely related to ferroptosis, so dietary management in targeted ferroptosis is considerable. Furthermore, accurately assessing oxidative stress and metabolic changes in lesions before the ferroptosis-related drugs ...
(+)-Negamycin, a natural dipeptide-like antibiotic, may restore some dystrophin expression in the skeletal muscles of mice with Duchenne muscular dystrophy, and this compound has been recognized as a potential therapeutic agent for diseases caused by nonsense mutations. In an effort to develop new...
Some of these functional effects are overlapping amongst a diverse array of pathological conditions like cancer, fibrosis, obesity, and inflammatory diseases. The image was created with BioRender.com Full size image As more translational studies unearth the CCN4-dependent molecular mechanisms, it is ...
used as an endosomal escape motif, with a siRNA therapeutics significantly increased its effectiveness in cancer cells214. However, proteins that belong to the enveloped capsules of viruses, like HA, are highly immunogenic and it may be challenging to move forward to clinical trials. An interesting...
Mutations in other genes involved in B cell development have also been described, giving rise to an XLA-like disease with a similar phenotype [20]. Both groups of patients can be identified by low or absent KREC levels. Early identification of this disease is important, as it facilitates ...