Various liver disorders such as alcoholic liver disease, non-alcoholic liver disease and primary sclerosing cholangitis have been associated with an altered microbiome. This dysbiosis may influence the degree of hepatic steatosis, inflammation and fibrosis through multiple interactions with the host's ...
The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providin
Various liver disorders such as alcoholic liver disease, non-alcoholic liver disease and primary sclerosing cholangitis have been associated with an altered microbiome. This dysbiosis may influence the degree of hepatic steatosis, inflammation and fibrosis through multiple interactions with the host9s ...
While the precise mechanism by which the microbiota contributes to atherosclerosis remains unknown, dysbiosis has been consistently associated with a leaky gut, with abnormalities of lipid and glucose metabolism that are associated with inflammation, and with the size of atherosclerotic plaques, which ...
Assessment of microbiota in the gut and upper respiratory tract associated with SARS-CoV-2 infection Background The human microbiome plays an important role in modulating the host metabolism and immune system. Connections and interactions have been found b... J Li,Q Jing,Li, JieHua, MingxiDi,...
Further comprehensive analyses highlighted the pleiotropic genetic variants and loci, potential shared causal variants, pleiotropic genes, biological pathways, and a potential genetic basis associated with gut microbiome. All these findings supported the role of GBA in the shared genetic etiology underlying...
To date, conclusions have been largely based on the population with CKD. Investigating the gut microbiota in patients with age-associated calcification in clinical settings will be a necessary next step to advance research [36]. An altered gut microbiota in patients with CKD with VC detrimentally...
An altered gut microbiota has been associated with several diseases, including obesity and diabetes, but the mechanisms involved remain elusive. Here we discuss factors that affect the gut microbiome, how the gut microbiome may contribute to metabolic diseases, and how to study the gut microbiome. ...
Several representative diseases, including CNS disorders (Alzheimer’s disease (AD), Parkinson’s disease (PD), and depression), metabolic disorders (obesity-related diseases), and intestinal disorders (IBD and regulation of the gut microbiota) are associated with the dysfunctional gut–brain axis (...
intestinal mucosal barrier is broken. Immune responses are initiated when naive immune cells recognized the antigen associated with Major Histocompatibility Complex class II molecules on the surface of antigen presenting cells [50]. Disrupted gut microbiota lead to the excessive activation of immune cells...