11.2.3 Disease ontology The Disease Ontology (DO) database [234] (http://disease-ontology.org) is a knowledge base related to human diseases. The current version stores information about 15,000 DO terms. The aim of DO is to connect biological data (e.g., genes) from a disease-centered...
Contact the Human Disease Ontology team: lschriml@som.umaryland.edu Citing the Symptom Ontology Please cite the following when using the Symptom Ontology: Schriml LM, Arze C, Nadendla S, et al. GeMInA, Genomic Metadata for Infectious Agents, a geospatial surveillance pathogen database. Nucleic...
a,bScatter plots depicting brain related diseases – using gene sets from the disease ontology database (http://disease-ontology.org/) – that are significantly enriched (adjustedp-value < 0.01, hypergeometric test with Benjamini–Hochberg correction) in a given microglial cluster, using the ...
A new approach to deciphering pathways of enterovirus 71-infected cells: An integration of microarray data, gene ontology, and pathway database The enterovirus 71 infection is associated with severe neurological disease in several clinical researches; however, the detailed gene network mechanisms o......
Additional work will also improve the possibilities of searching the database. Here the Gene Ontology [43] can be used to index the database. This would allow users to use Gene Ontology terms to search the database. Finally, it is desirable to optimise the database to gain lower response ...
The current version of the Human Disease Ontology (DO) (http://www.disease-ontology.org) database expands the utility of the ontology for the examination and comparison of genetic variation, phenotype, protein, drug and epitope data thro... WA Kibbe,C Arze,V Felix,... - 《Nucleic Acids...
The disease names were also normalized based on the standardized classification vocabulary of Disease Ontology (http://www.disease-ontology.org/). Figure 1 A flowchart of constructing Circ2Disease. Full size image CircRNA-miRNA-gene network construction As circRNAs may act as miRNA sponges, we ...
These two components make it possible to semantically query the ADNI database in order to support data extraction in a more intuitive manner. Results: We developed: i) a detailed computational ontology for clinical multimodal datasets from the ADNI repository in order to simplify the access to ...
药物与疾病靶点之间的交集靶点通过Clue GO(https://cytoscape.org)插件进行基因本体(gene ontology,GO)富集分析(BP,MF,CC)和通过DAVIDv6.8(https://david.ncifcrf.gov/)数据库分析信号通路(KEGG)。通过Cytoscape v3.8.2(https://cytoscape.org)软件构建多为网络可视化分析,初步推测中药复方治疗牙周疾病的作用机制...
We also performed a Gene Ontology (GO) enrichment analysis on the 121 genes containing filtered PPA SNVs and indels and also on the 1,365 genes using unfiltered PPA SNVs and indels. However, no GO term was significantly enriched (see Additional file3). ...