和Gene Ontolgy类似,Disease ontology简称DO, 所有的疾病信息也是采用了一个有向无环图的拓扑结构,所有数据库中的信息存储了一个obo文件中供下载,链接如下 http://www.disease-ontology.org/downloads/ 同时该网站也体用了API, 方便应用程序获取信息,API URL的格式如下 http://www.disease-ontology.org/api/meta...
和Gene Ontolgy类似,Disease ontology简称DO, 所有的疾病信息也是采用了一个有向无环图的拓扑结构,所有数据库中的信息存储了一个obo文件中供下载,链接如下 http://www.disease-ontology.org/downloads/ 同时该网站也体用了API, 方便应用程序获取信息,API URL的格式如下 http...
The Disease Ontology (DO) is a community-driven, open source ontology designed for the semantic integration of biomedical datasets that are associated with human disease, under the principles of the Open Biomedical Ontologies Foundry. From: Encyclopedia of Bioinformatics and Computational Biology, 2019 ...
The Common Alzheimer's Disease Research Ontology (CADRO) of the National Institute on Aging and the Alzheimer's Association; the International Alzheimer's and Related Dementias Research Portfolio (IADRP; iadrp.nia.nih.gov) provides the basis for the description of the biological processes in AD ...
Younesi E, Malhotra A, Gu¨ndel M, Scordis P, Kodamullil AT, Page M, Mu¨ller B, Springstubbe S, Wu¨llner U, Scheller D, Hofmann-Apitius M (2015) PDON: Parkinson's disease ontology for representation and modeling of the Parkinson's disease knowledge domain. Theor Biol Med Model...
We sought to identify the most likely gene mediators of thetrans-pQTLs using the ProGeM bioinformatics tool18, which utilizes genomic (for example,cis-eQTL) and biological (for example, gene ontology (GO) and pathways) annotation data from multiple sources. For sometrans-pQTLs, we identified ...
Combined SPOKE network of all shortest paths to AD node (Disease Ontology ID: 10652) for the top 25 input features (bolded) from matched AD model at every time point. Network is organized based on the number of time point model occurrences (yaxis) and eccentricity of a node in the subnetw...
In the example, the edge connecting Aniridia type 1 and variant rs121907928 is classified as CausalMutation in the DisGeNET association type ontology (shown in purple) whereas the edge connecting Aniridia and variant rs200015827 is classified as GeneticVariation in the DisGeNET association type ...
Most of the target processes identified in the Common Alzheimer’s Disease Research Ontology (CADRO) are represented by novel agents in trials. Inflammation and synaptic plasticity/neuroprotection are the CADRO categories with the largest number of novel candidate therapies. Within these categories, ...
We further compared those annotations labeled as ETHN to the Ethnicity Ontology [81, 82] and SNOMED Ethnic Group [83] gathered from NCBO BioPortal, and found 74.3% of them overlapped with those two ontologies. Notably “African Americans”, “Brazilian”, “Nepalese”, “Yupik”, and “Roma...