Localized or general muscle weakness is the predominant symptom and is induced by the antibodies. Patients are grouped according to the presence of antibodies, symptoms, age at onset and thymus pathology. Diagnosis is straightforward in most patients with typical symptoms and a positive antibody test...
249 For instance, the upregulation of Amd1 may foster cell proliferation, while the downregulation of Cacna1d could affect the electrophysiological properties of the heart.249 These alterations might have short-term beneficial impacts on cardiac health but could also pose long-term risks for disease...
Graves’ disease (GD) is an autoimmune disease that primarily affects the thyroid gland. It is the most common cause of hyperthyroidism and occurs at all ages but especially in women of reproductive age. Graves’ hyperthyroidism is caused by autoantibodi
When the mutant SPCA pump is overexpressed in model cells, its level of protein expression is extremely low, despite normal levels of mRNA, and correct localization to the Golgi compartment.53,54 As mentioned earlier, Hailey-Hailey disease shares phenotypic properties with Darier disease; however,...
IL-6 levels were associated with thymic atrophy. Our findings reveal an association between complex CHD and thymic atrophy, resulting in reduced thymic output. Consequently, thymus preservation during cardiovascular surgery could significantly enhance immune function and the long-term health of CHD ...
causes Cushing’s syndrome. This kind of tumor can form in an organ that doesn’t naturally produce ACTH, but because of the tumor, it begins to make a lot of it. These tumors can be cancerous or noncancerous. They’re usually found in the lungs, pancreas, thyroid, or thymus gland....
Tick-borne diseases constitute a major constraint of livestock production and have considerable economic impact [1]. In general, tick-borne protozoan diseases (e.g. theileriosis and babesiosis) and rickettsial diseases (e.g. heartwater or cowdriosis and anaplasmosis) are major health and manag...
From the studies just discussed, it can be concluded that TCDD and related compounds cause immune alterations, particularly of the thymus-dependent immunity. The findings in humans correlate in qualitative terms with the findings in experimental animals, including the sensitivity of the developing immune...
Primary report on video assisted thoracic surgery (VATS)for disease of thymus gland by single working pore电视胸腔镜外科单操作孔胸腺疾病目的 探讨单操作孔胸腔镜手术治疗胸腺疾病的可行性.方法 2009年1月至2010年12月,采用单操作孔胸腔镜手术治疗胸腺疾病32例.操作孔位于腋前线第3或4肋...
Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate any UBIQ-mediated ...