Pathologic diagnosis was nodular sclerosis Hodgkin's disease of the thymus. The patient received 6 cycles of ABVD (Adriamycin [doxorubicin], bleomycin, vinblastin and dacarbazine) and mediastinal radiotherapy.
The thymus undergoes progressive age-dependent atrophy with a loss of cells being generated and exported, therefore, hormone-based therapies are being developed as an alternative strategy to rejuvenate the organ, as well as to augment thymocyte proliferation and the export of mature T cells to ...
78,79 In addition to these potential regulatory influences, another important mechanism of control is central tolerance caused by positive and negative selection of T cells and B cells in the thymus, where thyroid antigens, including the TSHR, are expressed.80,81 Regulation of thymic gene ...
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Acute infection byTrypanosoma cruzi(the causative agent of Chagas disease) induces thymic atrophy through glucocorticoid-mediated thymocyte depletion, which can be counteracted by exogenous prolactin Abstract The physiology of the thymus, the primary lymphoid organ in which T cells are generated, is cont...
n, Western blot for Elf4 in mouse thymus. o, Sanger sequencing genotyping of Trp250Ser mice. p, Relative allele usage of B.2 (X/Trp251Ser) PBMCs. q, Relative allele usage (X/Trp250Ser) of mouse CD4+ or CD8+ cells. r, Percentage of perforin+ CD8+ T cells (WT n = 6, ...
Yinon Y, Zalel Y, Weisz B, Mazaki-Tovi S, Sivan E, Schiff Eet al. Fetal thymus size as a predictor of chorioamnionitis in women with preterm premature rupture of membranes.Ultrasound Obstet Gynecol2007;29: 639–643. ArticleCASPubMedGoogle Scholar ...
Evidence for the importance of specific antigen in the initiation of disease comes from transgenic expression of the H/K ATPase β subunit in the thymus which renders mice tolerant, leading to a failure to develop gastritis after thymectomy (Alderuccio et al., 1993). Genetic studies have identi...
In these birds, CAV causes anemia, aplasia of the bone marrow, and atrophy of the thymus, spleen, and bursa of Fabricius (Santen et al., 2004). Adenovirus Adenoviruses are nonenveloped double-stranded DNA viruses that replicate in the nucleus of the cell, producing inclusion bodies. The ...
MDV transforms CD4+ T cells approximately three weeks post infection and subsequently leads to atrophy of the thymus, the apoptosis of infected T cells and the development of MD lymphomas38. In addition, the expression of PD-1 was increased on CD4+ T cells of virus-infected birds at 21 dpi...