Using quantitative spatial analysis of mouse and postmortem human brain tissues, we found that oligodendrocytes expressing a key DOL marker (SERPINA3N/SERPINA3 accordingly) are present in the cortex in areas of brain damage and are enriched near Aβ plaques. In postmortem human brain tissue, the...
In the pre-ADHD era, when child sciences established themselves as academic fields of study and special education expanded quickly, brain-related psychiatric labels like “minimal brain damage” (MBD, later “dysfunction”) were often used for inattentive or hyperactive children. These diagnoses seem...
on the symptoms of Parkinson’s. Sugar is not on that list because sugar is not considered a drug. The idea behind these studies is to identify a drug that will provide some relief to symptoms. Sugar is undoubtedly one of the most toxic substance that exists in the world today. I know ...
Parkinson disease (PD) 帕金森病is a degenerative condition退行性疾病 of the brain associated with motor symptoms (slow movement动作迟缓, tremor震颤, rigidity僵硬 and imbalance不平衡) and other complications including cognitive impairment认知障碍...
Advances in sequencing and high-throughput techniques have provided an unprecedented opportunity to interrogate human diseases on a genome-wide scale. The list of disease-causing mutations is expanding rapidly, and mutations affecting mRNA translation ar
Parkinson disease (PD) 帕金森病is a degenerative condition退行性疾病 of the brain associated with motor symptoms (slow movement动作迟缓, tremor震颤, rigidity僵硬 and imbalance不平衡) and other complications including cognitive impairment认知障碍, mental health disorders精神障碍, sleep disorders睡眠障碍 and...
We developed the GBPN with 1,466 nodes and 107,423 edges and consequently the mc_GBPN with forty-one modularity classes. A list of the ten most influential nodes were identified from the mc_GBPN. These notably include Riluzole, stem cell therapy, cannabidiol, and VK-0214, with proven evi...
And in May 2023, Koselugo, an orphan drug that slows or reduces tumor growth, was approved in China and added to the national insurance list in December. “For neurofibromatosis patients, 2023 was like the year of rebirth,...
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Identification of PD biomarkers is crucial for early diagnosis and to develop target-based therapeutic agents. Integrative analysis of genome-scale metabolic model
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