Anaesthesia of a Disease Model in Medaka Tomohiro Ueno1, Hirokazu Suzuki1, Masahiro Hiraishi1, Hideaki Amano2, Hidenao Fukuyama3 & Naozo Sugimoto1 In medical and pharmacological research, various human disease models in small fish, such as medaka (Oryzias latipes), have been ...
Each participant’s genetic ancestry is algorithmically determined in the projection step. For each condition, an ancestry calibration model is applied to each participant’s z-scores based on model parameters derived from the All of Us Research Program (Calibration) and an adjusted z-score is ...
Intermittent fasting alleviates the increase of lipoprotein lipase expression in brain of a mouse model of Alzheimer’s disease: possibly mediated by beta-hydroxybutyrate. Front. Cell Neurosci. 12, 1 (2018). Article PubMed PubMed Central Google Scholar Kawarai, T. et al. A homozygous mutation...
4.3. Prediction Model of NBLDA As illustrated in Figure 4, we can model the prediction problem of potential lncRNA–disease association as the problem of resource allocation on the lncRNA–disease bipartite network. According to the assumption that functionally similar lncRNAs tend to show similar ...
The uptake of hematoporphyrin by the atherosclerotic plaque toward the aortic wall was detected in an atherosclerotic rabbit model [81]. This study concluded that hematoporphyrin can prevent the growth of smooth muscle cells and decrease atheroma after approximately two weeks of therapy in comparison ...
targeting FBXO32 is a promising potential therapeutic strategy to inhibit the progression of lung adenocarcinoma and improve the prognosis of patients. In our follow-up study, we plan to design a small molecule inhibitor of FBXO32 and construct an in vivo model in nude mice to investigate ...
Together, our results unveiled brain circRNAs associated with irreversible disease progression in an AD mouse model that is also affected in AD patients and identified novel molecular mechanisms underlying the dysregulation of conserved circRNA pathways contributing to AD pathogenesis. ...
www.nature.com/scientificreports OPEN received: 16 January 2015 accepted: 05 February 2016 Published: 25 February 2016 Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model Pernille Bøttger1,2,3, Simon Glerup1,4, Bodil...
In addition to accounting for a priori covariates, we ran a separate Cox model accounting for wear time, which was considered to be a time-varying covariate. Specifically, wear time was defined as the number of hours in a day that contained non-zero step counts. We also performed trajectory...
Yet, in practice both protective and preemptive changes in behavior come with costs. This paper proposes a stochastic network disease game model that captures the self-interests of individuals during the spread of a susceptible-infected-susceptible disease. In this model, individuals strategically ...