Indian childhood cirrhosis is associated with high liver copper concentrations and progressive liver disease with a high mortality. Early treatment with penicillamine was found to reduce mortality and reverse liver damage. We aimed to define the clinical features of copper-associated liver disease out...
The level of the apo-form of the copper enzyme ceruloplasmin (CP) is an established peripheral marker in diseases associated with copper imbalance. In view... Concetta,R.,Capo,... - 《Biometals》 被引量: 89发表: 2008年 Cerebrospinal fluid tau, Abeta1-42 and inflammatory cytokines in patie...
As an essential micronutrient, copper is required for a wide range of physiological processes in virtually all cell types. Because the accumulation of intracellular copper can induce oxidative stress and perturbing cellular function, copper homeostasis is tightly regulated. Recent studies identified a nov...
3f). This organelle could represent a degenerated mitochondrion associated with a lysosome, as these two organelles were recently discovered to interact directly via their membranes51. Indeed, this mitochondrion and a similar neighboring organelle are seen interacting with single membrane-bound ...
The following tests were normal or negative: routine blood studies, serum copper, ceruloplasmin and cerebrospinal fluid examination. There was not Kayser-Fleicher ring, and fundoscopic examination revealed no abnormalities. Levodopa was introduced and response was good for more than ten years, despite...
Trace levels of zinc and copper have been determined in the aorta from individuals with known histories of coronary heart disease (experimental group) and from individuals without a history of heart disease (control group) or any condition with an alleged or known association with trace zinc and ...
Deficiency in docosahexaenoic acid (DHA), a brain-essential omega-3 fatty acid, is associated with cognitive decline. Here we report that, in cytokine-stre... WJ Lukiw,JG Cui,VL Marcheselli,... - 《Journal of Clinical Investigation》 被引量: 1369发表: 2005年 Omega-3 fatty acid treatment...
Wilson disease is a severe genetic disorder associated with intracellular copper overload. The affected gene, ATP7B, has been identified, but the molecular events leading to Wilson disease remain poorly understood. Here, we demonstrate that genetically engineered Atp7b−/− mice represent a ...
Copper homeostasis and cuproptosis in central nervous system diseases Zhipeng Zhu ,Min Song &Min Chen Article 21 November 2024|Open Access MLKL deficiency elevates testosterone production in male mice independently of necroptotic functions Shene Chiou ...
developing PD75,76. Supporting this, studies have shown a higher incidence of PD in people exposed to heavy metals. Gorell et al. reported an increased risk of PD in those exposed to copper, manganese and lead77. For example, workers in the top quartile for chronic occupational exposure to...