Abstract Numbers of B cells spontaneously secreting Ig (IgG, IgA, and IgM) were determined by a plaque‐forming cell (PFC) assay simultaneously in the peripheral blood and bone marrow of normal individuals, patients with systemic lupus e... AS Fauci,HM Moutsopoulos - 《Arthritis & Rheumatism...
Disease activityIronRheumatoid arthritisZincThis study aims to compare the concentrations of circulating levels of iron, zinc, and copper in blood samples of rheumatoid arthritis (RA) patients which determine the correlations with inflammation and disease activity. A total of 102 RA patients and 66 ...
Atherosclerosis is a chronic inflammatory disease characterized by plaque accumulation on the arterial walls, leading to narrowing and hardening of the arteries [43]. This process can result in serious complications, including coronary artery disease (CAD), stroke, and peripheral artery disease [44,45...
Cuproptosis is one of the hotspots of current research, and its related molecular mechanisms become increasingly clear due to scholars’ increasing cognizance of the importance of copper homeostasis and copper-induced cell death in disease. Recently, copper-induced cell death has been more studied in...
Wilson's disease- a rare inherited disorder of copper metabolism; copper accumulates in the liver and then in the red blood cells and brain hepatolenticular degeneration congenital disease,genetic abnormality,genetic defect,genetic disease,genetic disorder,hereditary condition,hereditary disease,inherited dise...
High levels of copper in the blood and urine and average or high levels of caeruloplasmin usually indicate that the patient has a condition which is affecting the excretion of copper from the body, such as liver disease. Certain types of medication may also cause copper levels to increase; ...
Red blood cell formation: Copper is a component of hemoglobin and helps transport oxygen throughout the body. Nerve function: Copper aids in the maintenance of myelin, the protective sheath around nerves. Immune support: Copper helps in the development and maintenance of immune system cells. ...
MD is an X-linked recessive disease that affects Cu metabolism and is caused by mutations in the ATP7A gene.52 The resulting loss of functional ATP7A in the intestine leads to reduced Cu efflux into the blood, an accumulation of Cu in enterocytes, and generalized severe systemic Cu deficiency...
Blood was collected from the saphene at the start and end of the study for Ceruloplasmin activity measurements. Mice were sacrificed at the end of the study and observed for macroscopic abnormalities, if any, and tumor tissues were excised and fixed immediately for IHC analysis. Mice were ...
Iron Metabolism and Mitochondrial Abnormalities in Friedreich Ataxia Friedreich ataxia is an autosomal recessive disease causing degeneration in the central and peripheral nervous system, cardiomyopathy, skeletal abnormaliti... Massimo,Pandolfo - 《Blood Cells Molecules & Diseases》 被引量: 99发表: 2002年...