Discovery and validation of colorectal cancer tissue-specific methylation markers: a dual-center retrospective cohort studydoi:10.1186/s13148-024-01735-6DNA methylation markersColorectal cancerAdvanced adenomaDiagnostic modelRandom forest algorithmEarly detection, diagnosis, and treatment of colorectal cancer ...
In the CHOP discovery cohort, the odds ratio (OR) of developing AKI with a raw CXCL9 concentration >200 pg/ml was 4.6 (95% CI 1.7-12.6; p<0.01). The OR of developing AKI with a raw CXCL10 concentration >0 pg/ml was 4.7 (95% CI 1.7-12.7; p<0.01). In the validation cohort,...
IntroductionThe SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach.doi:10.1016/j.trci.2019.09.005John Wiley & Sons, LtdAlzheimer's & Dementia: Translational Research & Clinical ...
149]. In general, a small set of cases and controls are studied for biomarker discovery where the serum or plasma samples undergo multiple processing steps such as immunodepletion, proteolytic digestion, enrichment, and optionally isotope labeling and fractionation to achieve glycopeptide-rich samples...
cerebrospinal alterations in cytokine levels appear to vary in sporadic vs familial FTD cases173, but the causes underlying the observations remain to be determined. One study also identified a decrease in circulating B cells in patients with FTD174, but these findings await validation in larger pat...
LGALS4, CEACAM6, TSPAN8, and COL1A2: blood markers for colorectal cancer-validation in a cohort of subjects with positive fecal immunochemical test result. Clin Colorectal Cancer. 2018;17:e217–e228. Article PubMed Google Scholar Jafari R, Rahbarghazi R, Ahmadi M, Hassanpour M, Rezaie J...
PCR validation of Alu insertion identified by in silico analysis in patients from the discovery cohort.Kinga, M. BujakowskaJoseph, WhiteEmily, PlaceMark, ConsugarJason, Comander
The validation cohort included 154 cases and 154 controls from a random population-based selection of 5,815 patients. Our approach enabled the collection of a large number of early-stage melanoma samples from population-based databases with extensive follow-up and a sufficient number of metastatic ...
Results /Conclusion: Six metabolites (inosine, hypoxanthine, mannose, asparagine, aspartate and glutamate) were validated by an independent cohort, all of them related with metabolic processes described as associated with TB infection. The findings of the study are according with the WHO Target ...
Abbreviations: D, day; vEEG, video-electroencephalography; *, 2 samples from sham-operated and 5 samples from injured animals (3 TBI−, 2 TBI+) that were used for small RNA sequencing in the discovery cohort were also included in the ddPCR analysis in the validation cohort. The 257 ...