Baseline characteristics of the discovery and replication cohorts.Sim, XuelingA. Jensen, RichardKamran Ikram, MFrances Cotch, MaryLi, XiaohuiMacgregor, StuartXie, JingVernon Smith, AlbertBoerwinkle, EricMitchell, Paul
The discovery and replication cohorts consisted of 462 and 133 patients respectively. Patients were clinically assessed using standard diagnostic interviews, and clinical variables including current treatments were recorded. Blood was collected and serum assessed for levels of 31 cytokines using a sensitive...
This may reflect the fact that our SCA cohort is more similar to the Oregon-SUDS cohort, both of which required documented CAD, than the validation ARIC and CHS cohorts which included more heterogeneous SCD cases, thus restricting the power to replicate associations with SCA/SCD in the setting...
This includes rsID, PubmedID, citation, sample descriptors (both discovery and replication), and reported gene; Supplementary Table 6 Bibliography and study descriptors for the largest published manuscript by trait in the NHGRI-EBI GWAS Catalog; Supplementary Table 7 Comparison of effect sizes (both...
For discovery and replication we used more than 3,300 independent individuals from KORA F3 and F4 with metabolite measurements of 131 metabolites, including amino acids, phosphatidylcholines, sphingomyelins, acylcarnitines, and C6-sugars. A linear regression approach revealed significant concentration ...
To verify replication, the optimal classifier was then validated in the second and combined cohorts for distinguishing Aβ status and other AD endophenotypes. 2.5. Mendelian randomization MR was used to investigate the causal relationship between amyloid and tau pathology. MR uses genetic variants as ...
A meta-analysis of an eGFR GWAS was conducted using the BBJ and TWB. Replication was performed using an independent TWB-derived replication dataset. The relevance of the eGFR to kidney function was validated through the associations of the eGFR with BUN, CKD, and ESKD in the TWB and BBJ. ...
The biology students will be creating an animation on one of three topics: DNA replication, DNA transcription and translation, and protein synthesis. They have three choices for software usage: do a stop-motion animation with video software to compile the images; use MIT Scratch to program a ...
individuals), focus on small numbers of candidate biomarkers, failure to correct for multiple comparisons, lack of correction for confounds, including age, behavior, and comorbid disorders, lack of correction for genetic factors in a highly heritable disorder, and the lack of replication cohorts [5...
(9.2, 95% CI: 8.02 – 10.489vs. 7.6, 95% CI: 6.698 – 8.525 months,p = 0.030) [79]. Nonetheless, the aforementioned clinical trials are constrained by single-center small participant cohorts and the absence of placebo controls, highlighting the imperative for further placebo controlled...