In goat breeds, the domestication followed by artificial selection for economically important traits have shaped genetic variation within populations, leading to the fixation of specific alleles for specific traits. This led to the formation and evolutio
This book provides a broad overview of the topic Bioinformatics with focus on data, information and knowledge. From data acquisition and storage to visualization, ranging through privacy, regulatory and other practical and theoretical topics, the author touches several fundamental aspects of the innovativ...
38 39 DESIGN 40 The design of any genetically encoded biosensor involves connecting an input modality, 41 which interacts in some way with the species to be measured, to an output modality, which 42 provides some quantifiable product (Figure 1). These modalities may be DNA, RNA and/or 43 ...
Methodology and study design, workflow, and bioinformatics. This figure presents implemented statistical tests (Recursive Feature Elimination, Pearson correlation, Chi-square test, and Analysis of Variance) for the exploratory data analysis to assess the differences in genomics and phenotypic features betwee...
1. Is there a definitive learning style test? Unfortunately, there is no single, universally accepted learning style test. Many available tests offer valuable insights, but it’s important to approach them with a critical mind and consider additional factors like individual preferences and learning ...
We calculated the over-representation of biomarkers assigned to specific pathways or regulons using Fisher’s exact test. The frequency of each functional category in the biomarker set was compared with the frequency in the “background set” corresponding to the whole set of genes encoded by the...
The protein-binding motifs (Supplementary data 3) derived by our method show significant E-values and p-values determined by Fisher's exact test, and are similar to the motifs derived by RNAcompete. For four RBPs (HuR, PTB, SF2/ASF, and FUSIP1) in Fig. 6, our motifs are similar to...
“Study design”). Many patients with SLE exhibit high levels of genes induced by type I IFN; these genes, known as the IFN signature, are a marker of disease severity [30,31] and a pathogenic feature of SLE. This feature of the disease, together with exposure to anti-IL-6 leads to...
Identifying periodically expressed genes across different processes (e.g. the cell and metabolic cycles, circadian rhythms, etc) is a central problem in computational biology. Biological time series may contain (multiple) unknown signal shapes of systemi
Additional file 1 shows the chromatin motifs with occurrence rates in inaccessible and accessible chromatin groups in genome-wide regions (P values < 0.01 by paired t-test). There are 1,453 motifs, totally, and 561 (38.6%) of them have higher occurrences in accessible regions than in ...