Small molecule drugs form the backbone of modern medicine’s therapeutic arsenal. Often less appreciated is the role that small molecules have had in advancing basic biology. In this Review, we highlight how resistance mutations have unlocked the potenti
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Our aim is to analyze the potential molecular mechanisms between these two diseases using bioinformatics and systems biology approaches. Methods To elucidate the link between PT and AD, we selected shared genes (SGs) with gene-disease-association scores of ≥ 0.1 from the Disease Gene Network (...
We have arranged this review as an 33 engineering cycle in which we will cover (i) "Designing" biosensors, (ii) "Building" biosensors, 34 including technologies to facilitate the use of biosensors in plants, (iii) "Testing" biosensors and 35 (iv) "Modeling" signaling and development, ...
Advancing Medical Imaging with Language Models: A Journey from N-grams to ChatGPT In this paper, we aimed to provide a review and tutorial for researchers in the field of medical imaging using language models to improve their tasks at hand. We began by providing an overview of the history ...
204, No. 8Clinical Use of an Autovideography Intervention to Support Recovery in Individuals with Severe Mental IllnessJournal of Psychosocial Nursing and Mental Health Services, Vol. 54, No. 5Older adult recovery: “What are we working towards?”Mental Health Review Journal, Vol. 21, No. 1...
While several experimental and FDA-approved carbohydrate biomarkers have been discovered (e.g., CA19-9 for monitoring pancreatic cancer, CA125 for monitoring ovarian cancer, and CA15-3 and CA27-29 for monitoring breast cancer; further details and examples can be found in the review by Ludwig ...
In this review, in silico and experimental strategies used for the rational design of new anti-TB drugs are presented; in addition, the chemical space distribution based on the structure and molecular properties of compounds with anti-TB and anti-P-type ATPase activity is discussed. The chemical...
The beautiful Church of the Incarnation in Montefrio, Spain was the setting for Ms. Malinda K. Reese’s singing of the 1300 year old Latin Rite monastic hymn “O Come, O Come Emmanuel.” The church was empty at the time of her visit and the natural acoustics of its design beautifully ...
Interestingly, in a review investigating the evolution of GnRHR family genes and its receptors, the following genes surrounding the mammalian GnRHR1 (STAP1, UBA6, GnRHR, TMPRSS11D, TMPRSS11A, TMPRSS11F, TMPRSS11E and YTHDC1) and retrieved in our analysis, are conserved in human, mouse ...