产品名称:Epithelial discoidin domain-containing receptor 1 ELISA Kit 检测范围:0.156-10 ng/mL 保存条件:2-8℃低温保存 保质期:6个月,所有试剂盒均提供批次。 试剂盒成分:酶标板,试剂,标准品等。 选型: 产品规格:96T/48T 96T指可以做94个标本-2个标准对照-84个样本 ...
Discoidin Domain Receptor 1 (DDR1) is a subfamily of receptor tyrosine kinases (RTKs) participating in cell adhesion, migration and invasion. From: Critical Reviews in Oncology/Hematology, 2021 About this pageSet alert Also in subject area: Pharmacology, Toxicology and Pharmaceutical ScienceDiscover...
DDR1, ID (Epithelial Discoidin Domain-containing Receptor 1, Epithelial Discoidin Domain Receptor 1, Tyrosine Kinase DDR, Discoidin Receptor Tyrosine Kinase, Tyrosine-protein Kinase CAK, Cell Adhesion Kinase, TRK E, Protein-tyrosine Kinase 3A, Protein-tyr ...
Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis and can contribute to disease development, yet the molecules responsible for sensing flow remain largely unknown. Here, we demonstrate that the discoidin domain recepto
DDR1-IN-2 (DDR1 inhibitor 7rh) (DDR1 inhibitor 7rh) is a potent, selective, ATP-competitive Discoidin domain receptor 1 (DDR1) inhibitor (IC50: 6.8 nM in cell-free kinase assays). 靶点活性 DDR1:6.8 nM (cell free), DDR2:101.4 nM (cell free) 体外活性 DDR1-IN-2 inhibited the ...
DDR1human brainmicroglia type 2oligodendrocytesBackground:Discoidin domain receptor tyrosine kinase 1 (DDR1) is present in multiple types of epithelial cells and is highly expressed in the nervous system. Previous studies have revealed that DDR1 is involved in schizophrenia (SCZ). Although the ...
Accumulating evidence suggests that a unique set of receptor tyrosine kinases, known as discoidin domain receptors (DDRs), plays a role in cancer progression by interacting with the surrounding collagen matrix. In this study, we investigated the expression and role of DDR1 in human gastric cancer...
A chimeric receptor, containing the extracellular domain of hPDGFRbeta fused to the transmembrane and intracellular regions of DDR1, also fails to mediate neuronal-like differentiation in stably transfected PC12 cells and is only weakly autophosphorylated. However, chimeric receptors, which are composed...
Discoidin domain receptor 1 (DDR1) is a member of a small subfamily of receptor tyrosine kinases that is involved in proliferation, apoptosis, cell morphogenesis, and differentiation (8). DDR1 is expressed in human postmeiotic germ cells of testis (9). The ligands of the DDR1 receptor are...
(O is hydroxyproline), which is recognised by an amphiphilic trench at the top of the DS domain. How collagen binding leads to DDR activation is not understood. GVMGFO-containing triple-helical peptides activate DDRs with the characteristic slow kinetics, suggesting that the supramolecular ...