Cardiovascular diseaseFibrosisThe discoidin domain receptors have been implicated as contributing to normal developmental and pathologic conditions in humans. Mutations in the DDR genes have been described in a number of human diseases. Some of these are now being modeled in mice, which have afforded...
Discoidin domain receptors: a proteomic portrait. Cell Mol Life Sci. 2014;71:3269–79. Article CAS PubMed Google Scholar Borza CM, Pozzi A. Discoidin domain receptors in disease. Matrix Biol. 2014;34:185–92. Article CAS PubMed Google Scholar Carafoli F, Hohenester E. Collagen ...
The membrane receptors that are responsible for recognising collagens and then transducing signals into the cells include four members of the integrin family (α1β1, α2β1, α10β1 and α11β1) and two members of the discoidin domain receptor family (DDR1 and DDR2). However, it ...
Pozzi Discoidin domain receptors in disease Matrix Biol, 34 (2014), pp. 185-192 View PDFView articleView in ScopusGoogle Scholar 11 M.K. Siu, C.Y. Cheng Extracellular matrix and its role in spermatogenesis Adv Exp Med Biol, 636 (2008), pp. 74-91 View in ScopusGoogle Scholar 12 A....
Discoidin domain receptor (DDR) 1 and 2 are transmembrane receptors that belong to the family of receptor tyrosine kinases (RTK). Upon collagen binding, DDRs transduce cellular signaling involved in various cell functions, including cell adhesion, proliferation, differentiation, migration, and matrix ...
The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that binds to collagen, is expressed in blood vessels, but evidence for a functional role during atherogenesis is incomplete. In the present study, we generated Ddr1(+/+);Ldlr(-/-) and Ddr1(-/-);Ldlr(-/-) mice and...
A tale of two collagen receptors, integrin β1 and discoidin domain receptor 1, in epithelial cell differentiation As increase in collagen deposition is no longer taken as simply a consequence but, rather, an inducer of disease progression; therefore, the understanding ... YC Yeh,HH Lin,MJ Ta...
3Discoidin domain receptors Thediscoidin domain receptors(DDRs) arereceptor tyrosine kinases(RTKs) that function ascollagen receptors[80,81]. There are two closely related receptors in this RTK subfamily: DDR1 and DDR2. The DDRs are the onlyRTKsthat interact with structural components of ECMs...
The Discoidin Domain Receptor 1 (DDR1) is one of the two members of a unique family of receptor tyrosine kinase receptors that signal in response to collagen, which has been implicated in cancer progression. Here, we examined the expression of DDR1 in prostate cancer (PCa), and assessed it...
4.13.2 Signaling pathways of discoidin domain receptors in CNS DDR1b and DDR1c comprised 15 tyrosine residues in the cytoplasmic domain. Furthermore, DDR1a has 13 and DDR2 has 14 tyrosine residues. The function of tyrosine residue is to induce ligand-associated phosphotyrosine sites that are ...