Bile acids serve a vital function in lipid digestion and absorption; however, their accumulation can precipitate liver damage. In our study, we probed the effects of dimethyl sulfoxide (DMSO) on bile acid synthesis and the ensuing liver damage in mice in
Biphenyl-pyridine hybrid II inhibits the PD- 1/PD-L1 interaction and shows anti-tumor activity in vivo [9]. Moreover, a pyrazole- biphenyl derivative III has been demonstrated to have an inhibitory activity against histone deacetylases and in vitro anti-cancer activity against several tested cell...
The title compound, C(9)H(9)N(5), is slightly twisted from planarity, with a maximum deviation of 0.0285 (13) Å from the pyridine plane for the C atom bearing the amino group. The cyano groups are on different sides of the pyridine plane, with C- and N-atom deviations of...