Reduce dose by 20-25% when changing from the oral formulation or intramuscular (IM) to intravenous (IV) therapy Prematureneonate Oral: 1st loading dose, 10-15 mcg/kg; 2nd and 3rd loading doses, 5-7.5 mcg/kg every 6-8 hours for 2 doses; maintenance: 5-7.5 mcg/kg/day divided every ...