Our analysis support previous data suggesting dose adjustment of digoxin in patients with impaired renal function but suggest a higher SDC may be acceptable in the acute setting when used for rate control. Our sample size is limited, and future studies should confirm our findings in critically ill...
A population of 105 patients (pts) with recent onset (< 72 hours) atrial fibrillation (AF) without clinical signs of heart failure were randomly treated with a single loading oral dose of propafenone (PFN) (600 mg) or digoxin (DIG) (1 mg... GL Botto,W Bonini,T Sroffoni,... - 《...
The dose was significantly higher in patients who had heart failure than those who did not, by a mean of 40 micrograms. Among the 100 patients for whom appropriate dose was calculated, the dose was as predicted in 28, one level too low in 34, two or more levels too low in 32, and ...
All were taking digoxin at baseline and were randomised to receive, in addition, either carvedilol (Group 1, 24 patients) or placebo (Group 2, 23 patients) for 3 months. Doses were titrated to a target dose of carvedilol 25 mg b.d. In a second double-blinded phase, digoxin was ...
ventriculararrhythmias. If not contraindicated, oral administration of multidose activated charcoal prevents enterohepatic recycling.Hemodialysisis not effective in digoxin toxicity; however,hemoperfusionwith charcoal or resin filters is efficient for such toxicity.131,132For more information, please refer to...
The area under plasma concentration versus time curve was calculated after the first dose and in steady state both for digoxin and felodipine. The ... N Rehnqvist,E Billing,L Moberg,... - 《Drugs》 被引量: 42发表: 1987年 Plasma digoxin concentration in children with heart failure. A dos...
Of 51 patients for whom HF was the only reason for digoxin therapy, diagnosis of HF was incorrect in 30 patients (24.2%). Other inappropriate indications were paroxysmal AF and undetermined indication for digoxin prescription. Concerning digoxin dose, 24 patients (19.4%) received one tablet (0.25...
Considering the variability observed, it appears that a rough dose linearity does exist for digoxin injected into the amniotic fluid. In 1I animals, we compared the digoxin concentration in plasma samples taken simultaneously from the fetal aorta and +umbilical vein. At the time of peak values, ...
(positive inotropes) that does not increase mortality at the traditional dose, and that it may block neurohormone systems like beta blockers or ACE inhibitors. This may explain study results suggesting that low-dose digoxin not only reduces the risk of hospitalization, but may also reduce the ...
low-dose digoxin with the Class II AAD bisoprolol for rate control in AF patients found no statistically significant difference in quality of life at 6 months, but adverse events were significantly less common with digoxin, further supporting the safety of low-dose digoxin (Kotecha et al., ...