0.25mg 【用法用量】 成人常用量。口服: 常用0.125〜0.5吗(半片・2片),每日一次,7天可达稳态血药浓度;若达快速负荷量, 可每6〜8小时给药0.25mg(1片),总剂量。75〜1.25mg/日(3-5片/日);维持量,每日- 次0.125〜0.5哨(半片-2片)。 小儿常用量。口服: 本品总量,早产儿0.02〜0.03mg/kg;...
1. Tritiated (12-3H) digoxin (0路05 mg/kg body weight) was administered intravenously to conscious dogs with circulatory volume overload induced by previous creation of aorto-caval fistulae. Dogs were killed after 5 min, 1, or 4 h, and the myocardium sampled. Digoxin was extracted and ...
9 Whitbeck MG, Charnigo RJ, Khairy P, et al. Increased mortality among patients taking digoxin—analysis from the AFFIRM study. Eur Heart J 2013; 34: 1481–88. 10 Gheorghiade M, Fonarow GC, van Veldhuisen DJ, et al. Lack of evidence of increased mortality among patients with atrial ...
The Digoxin Investigation Group trial has multiple flaws in the trial design for the fi ndings to be universally applicable.Digoxin in low serum concentrations(0.5-0.9ng/mL)has been shown to decrease mortality in heart failure patients.Multiple trials in different patient populations also show ...
DigoxinThe article presents a case study of a 28-year old pregnant woman who developed digoxin toxicity that resulted to hyperkalaemic paralysis after receiving an extraplacental injection of digoxin.Reactions Weekly
A calibration curve was plotted over the range 0.2–50 ng/mL (R2 = 0.9998), and the method was successfully applied to study pharmacokinetics in rat following a single oral administration of digoxin (0.05 mg/kg). Four additional steroid saponins (digitoxin, deslanoside, ginsenoside ...
A calibration curve was plotted over the range 0.2–50 ng/mL (R2 = 0.9998), and the method was successfully applied to study pharmacokinetics in rat following a single oral administration of digoxin (0.05 mg/kg). Four additional steroid saponins (digitoxin, deslanoside, ginsenoside ...
To investigate the possibility of altered digoxin receptor binding properties in neonates, we compared digoxin binding with erythrocytes from neonates and adults. Neonatal erythrocytes had two and a half times as many digoxin binding sites as adult erythrocytes. The neonatal "receptors" also had ...
Captopril betters digoxinInpharma Weekly -doi:10.1007/BF03285825Springer International PublishingInpharma
(2) Twelve healthy volunteers participated in this open, randomized, 2-period crossover study, in which the effects of dipyridamole (300 mg/d for 3 days) versus placebo on the pharmacokinetics of a single oral dose of digoxin (0.5 mg) were compared. MDR1 genotyping (exon 26, C3435T) ...