Meaning These findings suggest that pembrolizumab has clinical activity in DMPM and should be considered as a treatment option in this rare disease. Abstract Importance Diffuse malignant peritoneal mesothelioma (DMPM) represents a rare and clinically distinct entity among malignant mesotheliomas....
The negative sign in the lag time indicates that the second channel of the pair is faster, and vice versa. The meaning of zero in lag time analysis is that there is no lag latency between the two channels in the pair within our system resolution. Since the data sampling speed of the ...
This idea was explored using ambiguous words for stimuli, as ambiguous words are known to have both strong (concepts related via dominant meaning) and weak associates (concepts related via subordinate meaning). Consistent with the prediction, mixed-handers showed equal ease in accessing both strongly...
Given these interesting but unexpected correlations, we evaluated if the genes composing our MacroSigs identified subpopulations of macrophages in scRNA-seq data from DLBCL cases (n = 17, comprising transcriptomes of 94,324 cells)37. We see that our MacroSigs were enriched within distinct clus...
The GO Chord plot on the left and the GO Enrichment score plot on the right in b and c represent the same meaning. d Sirt6 knockdown induced increased apoptosis rates in LY1, LY8, and Val cells as assessed by flow cytometric analysis with Annexin V-PE/7AAD staining. e Sirt6-depletion...
-based biomarkers as deduced from this review and grouped according to their potential meaning (diagnostic, prognostic, predictive, monitoring) in different phases of the disease process. The blood-based biomarkers mentioned here are selected based on the number of studies measuring the biomarker and ...
Genetic counselling is essential in providing a personalized interpretation of the results, with special emphasis on the meaning of susceptibility, the risk for other family members to develop the disease and the limited predictive value of positive and negative results. Once provided with this ...
A major problem in the treatment of DIPG is its delicate location and diffuse spread in the pons, meaning that radical surgical resection is not an option. Radiotherapy is a standard treatment for DIPG, often showing tumor reduction and clinical improvement, although these effects are always ...
The meaning and relevance of B-cell receptor structure and function in chronic lymphocytic leukemia. Semin Hematol 2014;51:158–167. 30 Guarini A, Chiaretti S, Tavolaro S, et al. BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated...
For a given participant, intra-subject synchronization was assessed using stimulus repetitions obtained within and across imaging sessions, meaning that an individual participant’s intra-subject synchronization map could include responses measured during movie viewings of the same repeated clip, across ...