The ability to tolerate and complete treatment was lower in patients with performance status ≥2 who were aged >50 years, where 2-year PFS was 43.5% (90% CI 27.9–58.0). Conclusions This trial demonstrates that
the histology of the former varied. Whether the definition of oligodendroglioma depends on the tumor’s histology or biological behavior anticipated by genotype, which is reflected in patient survival, is a matter for future debate. The current definition ...
In a randomised evaluation of molecular guided therapy for diffuse large B-cell lymphoma with bortezomib (REMoDL-B), an open-label, adaptive, randomised controlled, phase 3 superiority trial, participants were recruited from 107 cancer centres in the UK (n=94) and Switzerland (n=13). Eligible...
Discrimination between the "midline" and "non-mid- line" structures for definition of DMG therefore lacks consensus. For the present study, we reviewed the inclusion crite- ria of DMG used in previous reports that focused upon the midline structures. We collected histone H3 K27M- mutant ...
A more accurate definition of COO, if compared with IHC, could be provided by GEP analysis such as the Nanostring® platform. In order to better evaluate the role of the association of lenalidomide to standard chemoimmunotherapy in different COO phenotypes, Nanostring® analysis in these patie...
Figure 1 summarizes the terminology and NIRS domains that will be described in this paper. Figure 1 A decision tree that provides a definition of the different forms of diffuse optical monitoring. Although nomenclature varies across the field, these are the definitions preferred by the authors. 2D...
According to the definition of events, 17 patients (23%) presented with an event, 16 patients with progression/relapse, and 1 patient with a death without progression. A total of 14 patients died: 13 deaths were related to lymphoma and 1 was a toxic death. On ITT analysis, the 2-year ...
Disease definition and classification play an important role for progress in human health. The taxonomies used directly reflect the underlying principles for best diagnosis, treatment, and prophylaxis. The more precise the underlying complexities are studied, and this knowledge links to the disease of ...
Double hit and double expressors in lymphoma: Definition and treatment. Cancer 2018, 124, 4622–4632. [Google Scholar] [CrossRef] [Green Version] Bolen, C.R.; Klanova, M.; Trneny, M.; Sehn, L.H.; He, J.; Tong, J.; Paulson, J.N.; Kim, E.; Vitolo, U.; Di Rocco, A....