Combinations and variation of these methods have radically changed the way to approach dogmatic questions in life sciences. Now, the challenge lies in understanding how co-expressed gene networks interact to control and execute cell fate decisions. It has become evident that tissue-specific and cell...
In the dedifferentiation process, cells that have lost the capacity to divide regain it under specific circumstances. The redifferentiation process, on the other hand, causes the cells to divide and create cells that lose their ability to divide once more but develop to carry out particular duties...
As a rule I tend to ask the most questions during the first few folds and then pick up the speed as the folds get to the finish – but that’s not a rule or anything. I also go back and forth on whether to have them unfold and observe the folding pattern that results. This year...
EvaluatioTaskSortthequestionsinto:Application,Analysis,EvaluationandSynthesisAddoneofyourownforeachcategoryTaskSortthequestionsinto:KnowledgeComprehensionApplicationAnalysisEvaluationSynthesisKnowsthedifferencebetweenfictionandnon-fictionUnderstandsthefeaturesofdifferentnon-fictiontexttypes(eg.reports,discussions)Canusethe...
One of the questions we have not answered in this work is the cellular origin of miR-203. Our data in organoids suggest a cell-autonomous effect on mammary gland cells, and indeed denote a clear luminal character. It has been published that miR-203 is activated during luminal epithelial di...
Open Questions What is the contribution of BM-infiltrating immune cells to the HSC and LSC niche? What are the molecular mechanisms of the interaction between immune cells, LSCs and niche cells? Do stress-induced alterations in hematopoiesis favor leukemia development and progression?
Open questions How are specific DUBs regulated during embryonic and postnatal development to achieve their functions in cell-fate determination? What are the mechanisms and substrates of DUBs whose mutations underlie developmental diseases? Which other DUBs cause developmental diseases? Can we utilize tools...
Immune cells were traditionally considered as major pro-inflammatory contributors. Recent advances in molecular immunology prove that immune cell lineages are composed of different subsets capable of a vast array of specialized functions. These immune ce
Here, we use a new approach to tackle these questions, which is to extract biologically intermediate states of differentiation from a single chronological time point. By sorting out separate cell populations from a single cell culture of asynchronized, dividing cells, we aimed to reduce the biologi...
Michael Janeczko MD, Douglas G Burrin PhD, in Gastroenterology and Nutrition: Neonatology Questions and Controversies, 2008 Tissue Growth Factors Another class of molecules that may be key growth factors for the neonatal gut can be generally categorized as polypeptides that are secreted locally and ac...