Human embryonic stem cellInsulin-secreting cellsIntroduction: Type I diabetes mellitus is caused by autoimmune destruction of the insulin-producing 尾-cells. A new potential method for curing the disease is transplantation of differentiated insulin- secreting cells from human embryonic stem cells. Methods...
22kAccesses 33Altmetric Metrics Abstract The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm...
Human embryonic stem cells (hESCs) are a valuable source of pluripotential primary cells. To date, however, their homogeneous cellular differentiation to specific cell types in vitro has proven difficult. Wnt signaling has been shown to play important roles in coordinating development, and we ...
Human embryonic stem cells (hESCs) have extensive self-renewal capacity and are competent to differentiate into any cell type of the body. They are valuabl... L Gerrard,L Rodgers,W Cui - 《Stem Cells》 被引量: 491发表: 2010年 Differentiation of Human Embryonic Stem Cells to Regional Specifi...
The TET family of 5-methylcytosine (5mC) dioxygenases plays critical roles in development by modifying DNA methylation. Using CRISPR, we inactivated the TET1 gene in H9 human embryonic stem cells (hESCs). Mutant H9 hESCs remained pluripotent, even though
The STEMPRO® Osteogenesis Differentiation Kit supports osteogenesis from bone marrow–derived hMSCs (Figures 2A and 2B), human adipose-derived stem cells (ADSCs) (Figure 2C), and hMSCs derived from human embryonic stem cells. Figure 2. Osteogenesis-induced differenti...
Human Pluripotent Stem Cell Differentiation Kits Product Summary Pluripotent stem cells encompass both embryonic stem (ES) and induced pluripotent stem (iPS) cells, which are terminally differentiated cells reprogrammed into a pluripotent state. ES/iPS cell differentiation into ectoderm, mesoderm, and ...
Human Pluripotent Stem Cell Differentiation Kits Product Summary Pluripotent stem cells encompass both embryonic stem (ES) and induced pluripotent stem (iPS) cells, which are terminally differentiated cells reprogrammed into a pluripotent state. ES/iPS cell differentiation into ectoderm, mesoderm, and ...
The STEMPRO® Adipogenesis Differentiation Kit supports adipogenesis from bone marrow–derived hMSCs (Figures 1A and 1B), human adipose-derived stem cells (ADSCs) (Figure 1C), and hMSCs derived from human embryonic stem cells. Figure 1. Adipogenesis-induced different...
Human neural developmentHuman embryonic stem cellNeural differentiationHuman neurodevelopment is a key process that is precisely controlled by signaling pathways, intrinsic factors and epigenetic modifications. The previous knowledge of human neurodevelopment has mainly archived from human structural development, ...