Differential gene expression, commonly abbreviated as DG or DGE analysis refers to the analysis and interpretation of differences in abundance of gene transcripts within a transcriptome (Conesa et al., 2016). From: Encyclopedia of Bioinformatics and Computational Biology, 2019 ...
This is because a mathematical definition of 'differential expression' as any non-zero difference does not correspond to the differential expression biologists seek. Furthermore, while some current methods account for multiple comparisons in hypothesis tests, they do not accordingly adjust estimates of ...
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Gene Expression ProfilingGene Regulatory NetworksDifferential coexpression analysis usually requires the definition of 'distance' or 'similarity' between measured datasets. Until now, the most common choice is Pearson correlation coefficient. However, Pearson correlation coefficient is sensitive to outliers. ...
and Strauss, (2) the criteria based on clinical grounds from Lanham and colleagues, (3) the criteria based on clinical grounds from the American College of Rheumatology, and (4) the criteria from the Chapel Hill Consensus Conference, which closely concur with the Churg and Strauss definition. ...
Little is known about gene-expression patterns of mycobacteria and the definition of differentially -expressed genes is central to understanding pathogenesis and virulence at a molecular level.doi:10.1385/0-89603-471-2:307Joseph A. ManganPhilip D. Butcher...
Current evidence suggests that cis-regulatory elements controlling gene expression may be the predominant target of natural selection in humans and other species. Detecting selection acting on these elements is critical to understanding evolution but rem
the genes whose expression changes across pseudotime vs. physical time. Understanding which definition is more biologically relevant is an open question. Another question is whether it is possible to integrate pseudotime with physical time to identify biologically relevant DE genes. Answering either questi...
This study was performed to test the hypothesis that systemic leukocyte gene expression has prognostic value differentiating low from high seizure frequency refractory temporal lobe epilepsy (TLE). A consecutive series of patients with refractory tempora
The gene expression profile, before folding begins in the maturing brain, was significantly different in the developing opercular cortex compared to the insula. The Sylvian fissure forms by the relative overgrowth of the frontal and temporal lobes over the insula, corresponding to domains of highly ...