These results indicate that the spheroid-forming cells within each CRC organoid consisted of two different types of cells; a cell which has the capacity of generating a small spheroid, an S-cell, and generating a large spheroid, an L-cell. During spheroid formation, an S-cell only gave ...
We determined the effects of the SELECT supplements on benign (primary), premalignant ( RWPE-1) and malignant (LNCaP) prostate epithelial organoids. While the supplements decreased proliferation and induced cell death in cancer organoids, they had no effect on the benign organoids. In contrast, ...
Here we directed murine intestinal crypts to form specialized organoids highly enriched in intestinal stem cells (ISCs), absorptive ENTs, secretory goblet cells, or Paneth cells. The morphological and morphometric characteristics of these cells in organoids were similar to those in vivo. The ...
Moreover, possible solutions such as reconstitution of 3D tissue-like structures (organoids) and bioreactor-based culture systems may help address the source of EVs and achieve clinical-scale yields of tissue-derived EVs. Conclusion In summary, this study represents a pioneering contribution in ...
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids Protein Cell (2020), pp. 1-5 View in ScopusGoogle Scholar 101 K. Al Huraimel, M. Alhosani, S. Kunhabdulla, M.H. Stietiya SARS-CoV-2 in the environment: modes of transmission, early dete...
organoids.52,53,54In addition to tumor vaccine, anti-CD3 and anti-EGFR (epidermal growth factor receptor) antibody-engineered exosomes could promote the binding of T cells to cancer cells for precise therapy.55Similarly, decorating exosomes with both anti-human CD3 and anti-human HER2 antibodies...
The potential clinical use of stem/ progenitor cells and organoids in liver diseases. Cells. 2022;11(9):1410. 58. Alison MR, Choong C, Lim S. Application of liver stem cells for cell therapy. Semin Cell Dev Biol. 2007;18(6):819–26. 59. Subba Rao M, Sasikala M, Nageshwar RD. ...
Further studying the potential use of organoids and iPSCs as patient-derived model systems is highly important, as they offer a limitless supply of donor cells based on their progenitor cells. iPSCs also have a unique potential advantage, as they can in principle be differentiated into any CF...
Analysis of exosomal proteins secreted from organoids derived from a colon carcinoma cell line showed that molecules known to be apically or basolaterally trafficked in general show different degrees of abundance in these 2 distinct exosome populations19. On the other hand, in the present study, ...
Martin S. Staege 2,†, Sarah Brandt 1, Jana Luetzkendorf 1, Henrike Lucas 3, Lutz P. Mueller 1and Thomas Mueller 1,* 1 Department of Internal Medicine IV, Hematology and Oncology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany ...