Whether cooling was shallow or deep, rapid cooling attenuated the influence of cold exposure on the immune response. It is suggested that the differences in response to slow and rapid cooling could depend on the different responses of the skin cold receptors, the dynamic phase of the activity ...
to detect structural variants and to decipher complex genomic regions such as immune-response (IR) genes. Maintaining high genetic diversity in a population is important to reduce the spread of diseases, allowing rapid adequate immune responses and limiting, e.g., parasite...
During the last decade, DNA-based immunization has been promoted as a new approach to prime specific humoral and cellular immune responses to protein antigens [8]. In mouse models, DNA vaccines have been successfully directed against a wide variety of tumors, almost exclusively by driving strong ...
AdC68 is a typical chimpanzee adenovirus with no pre-existing immunity in the majority of humans36. It has similar immunogenicity to that of AdHu5, and can elicit both humoral and cellular immune responses37. Compared with the AAV vector, the adenoviral vector exerts a relatively short-term ...
Moreover, CS-coated PLGA NPs present an efficient and safe mucosal immune delivery system for FMDV DNA vaccine. Data from the current study provide a foundation for understanding and further evaluating protective immune responses in pigs. Introduction Foot-and-mouth disease (FMD) is one of the ...
Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis Lin Lin, Tingxuan Huang, Lizhi Li, Yang Lin, Feng Chen, Ziyi Zheng, Jie Zhou, Yizhe Wang, We...
The quality of immune responses is a critical factor in defining protective responses. Analy- sis of gp140-specific T cell responses revealed that splenocytes from mice immunized with poly (I:C) presented the highest numbers of IFN-γ secreting cells. Preclinical studies ...
Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7 2020, Journal of Biological Chemistry Citation Excerpt : Thus, a role for GBP2 in constraining MNV replication is not restricted to murine macrophages but also extends...
and Sela, M.: Contribution of different cell types to the genetic control of immune responses as a function of the chemical nature of the polymeric side chains (poly-L-prolyl and poly-DL-alanyl) of synthetic immunogens.J. Exp. Med. 135:1009–1027, 1972. Google Scholar Štark, O., ...
This is particularly important since it is acknowledged that adjuvants can also play a critical role in promoting or guiding specific types of adaptive immune responses, by modulating differentiation of Th cells [7,[15], [16], [17], [18]]. To induce long-term protection, it is considered...