It is noteworthy that the strength of surrogacy of these intermediate endpoints in targeted therapy is greater than that in immunotherapy.According to the arm-level and trial level-analysis, we suggest that in phase II and III trials of targeted therapy and immunotherapy for NSCLC patients: 1) ...
The content of sex pheromone, Bombykol, in the silkworm female moths and its periodic change were compared among 3 strains having different pheromone response in the male moth. The pheromone content of the female moth showed the periodic change; the pheromone increased in photophase period and de...
In females, there was no significant association between the GNRI or ALM index and HGS. These suggest that, for both sexes, nutritional supplementation and exercise should be recommended as the primary intervention for improving strength; however, other interventions for improving muscle quality could ...
aAlthough most trials use equal randomisation (such as 1:1 for two groups), it is helpful to provide the allocation ratio explicitly. For drug trials, specifying the phase of the trial (I-IV) may also be relevant. 虽然多数试验使用相等的随机化(例如1:1为二个小组),明确地提供分派比率是有用...
(MATernal Immunization Study for Safety and Efficacy) phase 3 trial reported a vaccine efficacy of 81.8% was observed against severe medically attended LRTD due to RSV in infants from birth through the first 90 days of life with high efficacy of 69.4% demonstrated through the first six months ...
Health, Lifestyle, and Psycho-Social determinants of Poor Sleep Quality during the early phase of the COVID-19 pandemic: a focus on UK older adults Deemed clinically extremely vulnerable. Front Public Health. 2021;9:753964. Article PubMed PubMed Central Google Scholar Kivipelto M, Mangia...
and we can finish it quickly. Then, without much impact on overall trials, we will proceed with our original schedule,” Kang said. “We’re not only pushing for local phase 2b and phase 3 studies but preparing a protocol to conduct a trial in Vietnam and get the WHO’s approval.” ...
Difference in ship motion and wave load in long and short crested irregular waves 3 response spectrum of a ship in long-crested waves is the area under the response spectral density curve: (4) where y is the spatial coordinate component; aij and εij are the amplitude and initial phase of...
arrow keys and were instructed to respond as soon as possible once they had made the decision (DECISION phase). The chosen stimulus was immediately highlighted by a gray frame (CONFIRMATION phase). Later, the rewarded stimulus was revealed in the center (FEEDBACK phase). ITI, inter-trial ...
Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care. 2012;35:556–64. Article Google Scholar Nguyen QD, Brown DM, Marcus DM, Boyer DS, Patel S, Feiner L. et al. Ranibizumab for diabetic macular edema: Results from 2 phase iii randomized trials: RISE and RIDE....