A comparison between phase-III trials and a phase-IV study of nalmefene in alcohol use disorder patients. Is there a difference?BARRIO, PABLOORTEGA, LLUISAGUARDIA, JOSEPRONCERO, CARLOSYUGUERO, LARAGUAL, ANTONIAdicciones
In the EU, the Phase 3b trial will evaluate eGOS after six months as the primary efficacy endpoint as in the Phase 3a trial. Based on the post hoc analysis of the initial Phase 2a and 3a trials, the drug infusion will start between four and 12 hours after injury, as opposed to six...
Gene targeting scores were compared between males and females using a linear regression model, while adjusting for relevant covariates: sex (Male and Female), race (White, Black or African American, Others and Unknown), age, smoking status (Ever-smoker and Never-smoker) and ischemic time for G...
The pheromone content of the female moth showed the periodic change; the pheromone increased in photophase period and decreased in the scotophase. The pheromone content of the female moth reached the maximal level between 33 and 36 hours after eclosion. Subsequently, the pheromone content of the...
For drug trials, specifying the phase of the trial (I-IV) may also be relevant. 虽然多数试验使用相等的随机化(例如1:1为二个小组),明确地提供分派比率是有用的。 为药物试验,指定试验(I-IV)的阶段也许也是相关的。 [translate] a文化素质 Cultural quality [translate] awish i was the bunny in ...
There is not only a significant relationship between the ALM index and HGS, but also some direct relationship between GNRI and HGS. In females, there was no significant association between the GNRI or ALM index and HGS. These suggest that, for both sexes, nutritional supplementation and exercise...
“To date we have no head-to-head phase 3 studies comparing the CDK4/6 inhibitors,” noted Kari B. Wisinski, MD, professor of medicine at the University of Wisconsin Carbone Cancer Center in Madison, Wisconsin, in a presentation of the data. ...
It has been argued that a target difference should always be both important and realistic [29], which would seem particularly apt when designing a definitive (Phase III) superiority RCT. In a sample size calculation for a RCT, the target difference between the treatment groups, strictly relates...
Cellid CEO Kang Chang-yul explains the results of phase 1 and phase 2a trials of AdCLD-CoV19, a Covid-19 vaccine candidate, at a virtual symposium on Tuesday. The company also said it planned to conduct a separate study early next year to fight the Delta variant. ...
被引量: 1发表: 2009年 Rationale and design of DECISION: a double-blind, randomized, placebo-controlled phase III trial evaluating the efficacy and safety of sorafenib in patient... Background The incidence of thyroid cancer and the number of patients who die from this disease are increasing gl...