The genomic diversity within a tumor and the interactions among various cell types within its microenvironment are considered key factors contributing to therapeutic efficacy. Specifically, women who harbor ger
while prostate cancer is the growth of a tumor in the prostate gland due to inherited genetic mutations in genes such asBRCA1,BRCA2,andHOXB13. Thus, this is the key difference between enlarged prostate and prostate cancer. Furthermore, the risk factors for an enlarged...
Mutations in tumor suppressor genes such as BRCA1, BRCA2, the PI3K/AKT/mTOR pathway, and PTEN can be related to the formation of multicentric breast cancer. Multicentric breast cancer can be diagnosed through mammography, histopathology, and genetic testing. Furthermore, treatment options for multi...
Basal-like breast cancer was delineated using this methodology and demonstrates significant overlap with so-called triple negative and BRCA1-associated breast carcinomas. This article describes the pathology and biology of these three groups of tumours and examines the relationship between them. ...
Higher cancer risk was related to BRCT domain of BRCA1 for breast cancer, and BRC repeats of BRCA2 for ovarian cancer. Parity was a risk-reducing factor among BRCA1/2 mutation carriers. Risk factors can be used for personalized preventive strategies of BRCA1/2 mutation carriers.Park, Ji ...
The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative ...
Anxiety did not differ significantly between groups. Reactions to materials differed on two items: "seemed to be prepared just for me" (76% TPM vs. 52% NPM; p < 0.001) and "told me what I wanted to know about BRCA1 and 2 testing" (98% TPM vs. 91% NPM; p<0.05). TPMs showed ...
Breast cancer happens when breast cells mutate and become cancerous cells, dividing and multiplying to create tumors, which include mutations in genes such as BRCA1, BRCA2, Tp53, HER2, etc. Fibroadenoma is caused by the changing levels of the hormone estrogen. ...