Ratner R, Nauck M, Kapitza C, Asnaghi V, Boldrin M and Balena R (2010) Safety and tolerability of high doses of taspoglutide, a once-weekly human GLP-1 analogue, in diabetic patients treated with metformin: a randomized double-blind placebo- controlled study. Diabet Med. 27:556-562....
In the AWARD-7 trial (which was not a CVOT) performed in T2DM subjects with moderate-to-severe CKD, once-weekly dulaglutide produced glycemic control similar to that achieved with insulin glargine, but showed evidence of reduced decline in eGFR (64). Other microvascular outcomes did not improve...
Behl T, Kotwani A. Exploring the various aspects of the pathological role of vascular endothelial growth factor (VEGF) in diabetic retinopathy. Pharmacological research. 2015 Sep:99():137-48. doi: 10.1016/j.phrs.2015.05.013. Epub 2015 Jun 6[PubMed PMID: 26054568] [16] Kador PF, Wyman M...
A healthy lifestyle score was constructed based on 4 well-established dementia risk factors (smoking status, physical activity, diet, and alcohol consumption) assessed at baseline using a touchscreen questionnaire. Participants scored 1 point for each of 4 healthy behaviors defined on the basis of ...
a subcutaneously injected glucose-responsive formulation that nearly does not trigger the formation of a fibrous capsule and that leads to week-long normoglycaemia and negligible hypoglycaemia in mice and minipigs with type 1 diabetes. The formulation consists of gluconic acid-modified recombinant ...
In the 4th week, the body weight of sham control rats increased significantly (p < 0.05), whereas STZ-induced diabetic rats revealed a significant decrease in weight as compared to the sham control rats. Figure 1. Effect of STZ-induced diabetes and treatment on metformin and A. paniculata ...
a, Eight-week-old TGR5fl/fl and TGR5ΔCM mice were injected with adeno-associated virus of serotype 9 (AAV9) through a tail vein to knock down DHHC4 under the transcriptional control of cardiomyocyte-specific troponin T promoter (5 × 1012 plaque-forming units per mouse). At 2 weeks...
After adaptation for 1 week, the db/db mice in the low-dose group (clinical dose) and high-dose group (2 × clinical dose) were orally administered 14.43 g/kg and 28.66 g/kg FX once a day, respectively. The db/m and control (db/db) groups were orally administered the same volume ...
only for the longevity stats to tip in favor of femalesduring the 1890s— an advantage that women have held ever since. Women are supposedly more vulnerable than men toinfectious diseases, but once male scientists got a grip on the microbes and brought those pesky critters to heel, women sta...
I don’t talk about it much, but alcoholism runs deep in my veins, much like it did my father who was an abusive alcoholic when I was a child. There was once a time when I could and would drink you under the table. The hard stuff was like water in my system. I loved the tast...