Additionally, the hierarchy between some concepts can also be inferred from their labels, such as “乳酸性酸中毒” (lactic acidosis) is_a “酸中毒” (acidosis). The construction of hierarchical relationships can provide feedback to the previous two steps by adding new terms and concepts. Non-...
In GSD Ia, there is a deficiency of enzyme glucose-6-phosphatase (G6Pase) that cleaves glycogen to glucose; thus, leading to hypoglycemia and lactic acidosis. Patients with GSD 1b have normal G6Pase enzyme activity; but have a deficiency of the transporter enzyme, glucose-6-phosphate ...
This large cohort study quantifies the association between metformin use and hospitalization with acidosis across the range of estimated glomerular
Renal tubular acidosis Drugs (such as Foscarnet, Clozapine, Antifungals, Antineoplastic agents, Lithium2, 3 and Antiviral medications) Congenital NDI It is triggered by: Irregular NDI, along with intracerebral calcification and mental retardation. X-linked mutation in the V2 ADH-receptor gene. Nephroge...
Based on the negative clinical experience with phenformin and the potential for metformin-associated lactic acidosis, the US Food and Drug Administration (FDA) issued a safety warning restricting metformin for patients with serum creatinine levels of 1.5 mg/dL or greater for men or 1.4 mg/dL or...
Islet cell destruction sec- ondary to SARS-CoV-2 infection can be an autoimmune pathophysiological mechanism, though this infection determines hyper- glycemia in patients with COVID-19. However, pre-existing DM predisposed patients to develop acidosis and ketoacidosis in cases of hospitalization for ...
A smaller number of patients (4500) were discharged after treatment for diabetic coma (ICD-9-CM 250.3), 10,800 for hyperosmolar coma (ICD-9-CM 250.2), and 18,800 for acidosis (ICD-9-CM 276.2). 16 Decompensated diabetes imposes a heavy burden in terms of economics and patient outcomes...
Only 22.9% of our patients were treated with MET, which is likely a consequence of previous recommendations to avoid this drug in HF because of concerns regarding lactic acidosis risk13. Nevertheless, MET was used in clinical practice and data on MET use in HF patients with DM eventually emerg...
There were no cases of mortality in patients with or without AKI. Conclusions and Relevance This study is the first to date to document that a high proportion of children hospitalized for DKA develop AKI. Acute kidney injury was associated with markers of volume depletion and severe acidosis. ...
Two large observational studies, however, demonstrated that metformin significantly reduced the risk of death and hospitalization compared to sulfonylurea monotherapy in patients with HF, without causing additional metabolic acidosis. In response to these results, FDA removed the warning for HF patients in...