200Altmetric Metrics Abstract We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and signal correction strategies for the processing of data-independent acquisition (DIA) proteomics experiments. DIA-NN improves the identification and qua...
DIA-NN - a universal software suite for data-independent acquisition (DIA) proteomics data processing. Conceived at the University of Cambridge, UK, in the laboratory of Kathryn Lilley (Cambridge Centre for Proteomics), DIA-NN opened a new chapter in proteomics, introducing a number of algorithms...
The --nn-fold 4 option (experimental) that ensures that each neural network in an ensemble is only used for prediction on samples it has not been trained on. Of note, these functions are normally not needed on 99% of datasets, however if the purpose is to benchmark the software and too...
At present, only a fraction of the information recorded in the complex DIA spectra is extracted by the software analysis pipelines. Here we present a software tool (DIA-NN) that introduces artificial neural nets and a new quantification strategy to enhance signal processing in DIA-data. DIA-NN...
We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and signal correction strategies for the processing of data-independent acquisition (DIA) proteomics experiments. DIA-NN improves the identification and quantification performance in conv...
1). In contrast to the direct extraction of “profile” ion mobility data as implemented in the Mobi-DIK module for OpenSWATH, the first software that was able to process dia-PASEF data14, we present an ion mobility module that starts the analysis from 2D-peak-picking, wherein a narrow ...
A user-friendly implementation is provided through the incorporation of the algorithms in the DIA-NN software and by the FragPipe workflow for spectral library generation. 展开 关键词: ION mobility PROTEOMICS SIGNAL separation DATA analysis TANDEM mass spectrometry IONIC mobility ION mobility spectroscopy...
DIA-NN - a universal software suite for data-independent acquisition (DIA) proteomics data processing. Conceived at the University of Cambridge, UK, in the laboratory of Kathryn Lilley (Cambridge Centre for Proteomics), DIA-NN opened a new chapter in proteomics, introducing a number of algorithms...
DIA-NN - a universal software suite for data-independent acquisition (DIA) proteomics data processing. Conceived at the University of Cambridge, UK, in the laboratory of Kathryn Lilley (Cambridge Centre for Proteomics), DIA-NN opened a new chapter in proteomics, introducing a number of algorithms...
9000 proteins in single injections recorded with a 93-min nanoflow gradient on timsTOF Pro 2, from 200 ng of HeLa peptides. A user-friendly implementation is provided through the incorporation of the algorithms in the DIA-NN software and by the FragPipe workflow for spectral library ...